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Pantoprazole (Injection)

Pantoprazole (pan-TOE-pra-zole)

Treats gastroesophageal reflux disease (GERD) and damage to the esophagus. Also treats high levels of acid in the stomach caused by a tumor (such as in Zollinger-Ellison syndrome). This medicine is a proton pump inhibitor (PPI).

Brand Name(s):

Novaplus Protonix, Protonix, Protonix IV

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to pantoprazole.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.
  • Your doctor will give you a few doses of this medicine until your condition improves and then switch you to an oral medicine that works the same way. Talk to your doctor if you have any concerns about this.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use ampicillin (Omnipen®), atazanavir (Reyataz®), digoxin (Lanoxin®), iron supplements (Feosol®, Fer-In-Sol®), ketoconazole (Nizoral®), methotrexate (Rheumatrex®, Trexall®), nelfinavir (Viracept®), or a blood thinner (such as warfarin, Coumadin®). Tell your doctor if you also use a diuretic (water pill, such as bumetanide, chlorothiazide, ethacrynic acid, furosemide, hydrochlorothiazide, indapamide, metolazone, torsemide, Bumex®, Demadex®, Diuril®, Edecrin®, Lasix®, Lozol®, or Zaroxolyn®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding or if you have liver problems, osteoporosis, or a history of low magnesium in your blood. Tell your doctor if you have problems with a lack of zinc in your body.
  • Check with your doctor right away if you notice changes in skin color or pain, tenderness, or swelling of the foot or leg.
  • This medicine may increase your risk of broken bones in the hip, wrist, and spine. This is more likely if you are older than 50, receive high doses of this medicine, or use it for 1 year or longer.
  • This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you take this medicine longer than 1 year or if you take it with digoxin or certain diuretics (water pills). Tell your doctor right away if you have seizures, dizziness, a fast or pounding heartbeat, or muscle spasms.
  • Tell your doctor right away if you have diarrhea that does not go away, stomach pain, and fever while taking this medicine.
  • You may be at risk for Clostridium difficile colitis (also called C diff) if you take this medicine. C diff is an inflammation of your large intestine that causes diarrhea. You have a higher risk of this condition if you are also using antibiotics, are elderly, or have other health conditions.Ask your doctor before you take any medicine to stop severe diarrhea.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dizziness, seizures, fast or pounding heartbeat, or muscle spasms or cramps
  • Redness, swelling, or pain where the needle is placed
  • Severe diarrhea that does not go away, stomach pain, fever
  • Pain, tenderness, or swelling of the foot or leg

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild diarrhea or stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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