Lisinopril/hydrochlorothiazide (By mouth)
Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Lisinopril (lye-SIN-oh-pril)
Treats high blood pressure. This medicine is a combination of an ACE inhibitor and a diuretic (water pill).
Prinzide, ZestoreticThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use if you are pregnant, or if you had an allergic reaction to lisinopril, hydrochlorothiazide (HCTZ), or a sulfonamide (sulfa) drug. Do not use this medicine if you have problems urinating, or you have a history of angioedema.
How to Use This Medicine:
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not use this medicine together with aliskiren if you have diabetes.
- Some medicines can affect how lisinopril/hydrochlorothiazide works. Tell your doctor if you are using any of the following:
- Cholesterol-lowering medicine
- Gold injections
- Insulin or oral diabetes medicines
- NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, or naproxen)
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have kidney, liver, or heart problems, high cholesterol, or a mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood). Tell your doctor if you have diabetes, glaucoma, gout, lupus, or a history of allergies or asthma.
- Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when you use them with this medicine.
- This medicine may cause the following problems:
- Intestinal swelling
- Liver problems
- Vision problems
- This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blurred vision, changes in vision
- Change in how much or how often you urinate, problems urinating
- Confusion, weakness, trouble breathing, numbness or tingling in your hands, feet, or lips
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Dry mouth, increased thirst, muscle cramps, fast, slow, pounding, or uneven heartbeat
- Fever, chills, sore throat, or body aches
- Lightheadedness, dizziness, or fainting
- Severe stomach pain (with or without nausea or vomiting)
- Unusual tiredness or weakness
If you notice these less serious side effects, talk with your doctor:
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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