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Cilostazol (By mouth)

Cilostazol (sye-LOE-sta-zol)

Treats a circulation problem in which too little blood flows into your leg muscles (intermittent claudication). Helps you walk longer distances with less pain.

Brand Name(s):

Pletal

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to cilostazol, or if you have heart failure or certain bleeding problems.

How to Use This Medicine:

Tablet

  • Take your medicine as directed.
  • You may be told to take a dose of the medicine two times each day, at least one-half hour before or two hours after breakfast and dinner.
  • Your leg pain may not get better right away. Some patients may need to use this medicine for 2 to 4 weeks before it starts to help. Others may need to use the medicine for 12 weeks before their leg pain is better.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using any antibiotics or antifungal medicines, such as erythromycin (EES®), clarithromycin (Biaxin®), ketoconazole (Nizoral®), itraconazole (Sporanax®), or if you are using diltiazem (Cardizem®), fluvoxamine (Luvox®), fluoxetine (Prozac®), nefazodone (Serzone®), sertraline (Zoloft®), omeprazole (Prilosec®), or aspirin. Your doctor may need to change your dose of cilostazol if you are also using these medicines.
  • Other medicines may also change the way cilostazol works. Give your doctor a list of all the medicines you use.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, liver disease, kidney disease, or bleeding problems.
  • Call your doctor if your symptoms do not improve or if they get worse.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain.
  • Dark-colored urine or pale stools.
  • Fast, pounding, or uneven heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Rapid weight gain.
  • Severe headache.
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, or stomach pain.
  • Leg cramps.
  • Loss of appetite.
  • Muscle pain, joint pain, or weakness.
  • Skin rash, or dry, thick skin.
  • Trouble sleeping.
  • Yellowing of your skin or the whites of your eyes.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014
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