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Celecoxib (By mouth)

Celecoxib (sel-e-KOX-ib)

Treats pain, including pain caused by arthritis (osteoarthritis, rheumatoid arthritis, or juvenile rheumatoid arthritis) in children and adults, ankylosing spondylitis, or menstrual cramps. This is a non-steroidal anti-inflammatory medicine (NSAID).

Brand Name(s):

Celebrex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction (including asthma) to celecoxib, or a sulfa drug (such as sulfamethoxazole, Bactrim®, Septra®). You should not use this medicine if aspirin or other NSAIDs (such as diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Ecotrin®, Motrin®, or Voltaren®) have ever caused you to have breathing problems, a rash, or other allergic-type reactions. Do not use this medicine right before or right after having coronary artery bypass graft (CABG), a type of heart surgery.

How to Use This Medicine:

Capsule

  • Take your medicine as directed.
  • It is best to take this medicine with food or milk, so it does not upset your stomach.
  • Use this medicine for the shortest time possible and in the smallest dose possible. This will help lower the risk of side effects.
  • If you cannot swallow the capsule, you may open it and pour the medicine into a teaspoon of applesauce. Stir the mixture well and swallow right away. Drink enough water after to make sure you swallow any excess medicine in mouth.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Any medicine that has been mixed with applesauce may be stored in a refrigerator and used within 6 hours.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using aspirin, fluconazole (Diflucan®), lithium (Eskalith®, Lithobid®), a blood thinner (such as warfarin, Coumadin®), or a steroid medicine (such as cortisone, dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, or Orapred®). Tell your doctor if you are also using a blood pressure medicine (such as enalapril, lisinopril, losartan, olmesartan, valsartan, Accupril®, Atacand®, Avapro®, Cozaar®, Diovan®, Hyzaar®, Lotrel®, or Zestril®) or a diuretic or "water pill" (such as furosemide, hydrochlorothiazide [HCTZ], torsemide, Demadex®, or Lasix®).
  • Tell your doctor if you are using other pain or arthritis medicine such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Ecotrin®, Motrin®, or Voltaren®.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding. You should not use this medicine during the later part of pregnancy, unless your doctor tells you to.
  • Make sure your doctor knows if you have a history of ulcers or other stomach problems. Tell your doctor if you have kidney disease, liver disease, anemia, aspirin-sensitive asthma, high blood pressure, congestive heart failure (CHF), certain genetic conditions (CYP2C9 (liver enzyme) poor metabolizer), or other heart or circulation problems.
  • This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.
  • This medicine might cause bleeding in your stomach or intestines. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, are in poor health, or using certain other medicines (a steroid medicine or a blood thinner).
  • Using this medication in certain patients under the age of 18 for the treatment of juvenile rheumatoid arthritis may increase the risk of disseminated intravascular coagulation (bleeding problem). Talk with your doctor if you have concerns about this.
  • Stop using this medicine and check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.
  • Serious skin reactions can occur during treatment with this medicine. Stop using this medicine and check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.
  • Tell your doctor if you or your child have unexplained weight gain or edema (fluid retention or body swelling) with this medicine.
  • Do not give this medicine to a child younger than 2 years old, unless your doctor tells you to.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash.
  • Bloody or black, tarry stools.
  • Change in how much or how often you urinate, bloody or cloudy urine.
  • Chest pain, shortness of breath, or coughing up blood.
  • Dark-colored urine or pale stools.
  • Fast or slow heartbeat.
  • Fever, chills, cough, sore throat, and body aches.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain in your lower leg (calf).
  • Rapid weight gain
  • Severe stomach pain.
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Skin rash or blisters with fever.
  • Sudden or severe headache, or problems with vision, speech, or walking.
  • Swelling in your hands, ankles, or feet.
  • Unusual tiredness or weakness, pale skin.
  • Vomiting blood or material that looks like coffee grounds.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Dizziness or headache.
  • Mild nausea, diarrhea, gas, heartburn, or stomach pain or upset.
  • Mild skin rash.
  • Muscle or joint pain.
  • Stuffy or runny nose.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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