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Ifosfamide (Injection)

Ifosfamide (eye-FOS-fa-mide)

Treats cancer of the testicles.

Brand Name(s):

Ifex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not receive this medicine if you have had an allergic reaction to ifosfamide or if you have trouble urinating. Do not receive this medicine if you are pregnant or breastfeeding.

How to Use This Medicine:

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use St John's wort, aprepitant (Emend®), fosaprepitant (Emend® injection), rifampin (Rifadin®, Rimactane®), sorafenib (Nexavar®), medicine to treat seizures (such as carbamazepine, fosphenytoin, phenobarbital, phenytoin, Dilantin®, Luminal®, or Tegretol®), or medicine to treat a fungal infection (such as fluconazole, itraconazole, ketoconazole, Nizoral®, or Sporanox®). Tell your doctor if you have received other cancer medicines or radiation treatments.
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Women should not become pregnant during therapy and men should not father a child while receiving this medicine and for 6 months after stopping it.
  • Make sure your doctor knows if you have kidney disease, liver disease, anemia, bones or bone marrow problems, brain disease, heart disease, lung problems, urinary tract problems, or any type of infection.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. This medicine may slow wound healing.
  • Tell your doctor right away if you have vision changes, confusion, dizziness, hallucinations, mood changes, seizures, or unusual tiredness while using this medicine. These may be symptoms of a serious brain disease, which can be caused by this medicine.
  • This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may increase your risk of certain cancers, such as lymphoma, leukemia, and thyroid cancer. Talk to your doctor if you have concerns about this risk.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate, painful or burning urination
  • Confusion, drowsiness, vision changes, hallucinations (seeing, feeling, or hearing things that are not there), or uncontrolled body movements
  • Fast, pounding, or uneven heartbeat or trouble breathing
  • Fever, chills, cough, sore throat, and body aches
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Red or dark brown urine
  • Severe nausea, vomiting, or diarrhea
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Hair loss
  • Mild nausea or vomiting
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 11/4/2014
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