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Lansoprazole (By mouth)

Lansoprazole (lan-SOE-pra-zole)

Treats stomach ulcers, gastroesophageal reflux disease (GERD), and conditions that cause your stomach to make too much acid, such as Zollinger-Ellison syndrome. Also helps heal a damaged esophagus. This medicine is a proton pump inhibitor (PPI).

Brand Name(s):

First - Lansoprazole, Heartburn Relief 24 Hour, Prevacid, Prevacid NapraPAC 375, Prevacid NapraPAC 500, Prevacid SoluTab, Prevacid Solutab, Prevpac, Rite Aid Lansoprazole, Topcare Lansoprazole, Triple Therapy

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to lansoprazole.

How to Use This Medicine:

Delayed Release Capsule, Liquid, Tablet Disintegrating, Delayed Release

  • Take your medicine as directed.
  • Follow the instructions on the medicine label if you are using this medicine without a prescription.
  • Take this medicine before you eat and for the full time of treatment, even if you begin to feel better after a few days.
  • Capsule: Swallow the capsule whole. Do not break, crush, or chew it.
    • If you cannot swallow the capsule, you may open it and spill the contents onto 1 tablespoon of applesauce, Ensure® pudding, cottage cheese, yogurt, or strained pears. You may also use 60 mL (1/4 cup) apple juice, orange juice, or tomato juice. Swallow this mixture right away. Do not chew or crush the granules. If you used juice, refill the cup 2 more times with juice and drink the remaining mixture.
  • Capsule given through a feeding tube: Open the capsule and mix the contents with 40 mL (about 2 1/2 tablespoons) of apple juice. Do not use any other liquid. Inject or pour the mixture into the nasogastric tube. Flush the tube with more apple juice to rinse all of the medicine from the tube.
  • Oral tablet: Dry your hands before you handle the tablet. Do not crush, chew, break, or cut the tablet. Place the tablet on your tongue, with or without water, and allow it to dissolve. Swallow the particles right away.
  • Oral tablet with an oral syringe: Dry your hands before you handle the tablet. Do not crush, chew, break, or cut the tablet.
    • 15-milligram tablet: Place the tablet in the oral syringe and add 4 mL (1 teaspoon) of water.
    • 30-milligram tablet: Place the tablet in the oral syringe and add 10 mL (2 teaspoons) of water.
    • Shake the syringe gently until the tablet dissolves and is mixed well.
    • Use the mixture within 15 minutes.
    • Refill the syringe with water. Use 2 mL (1/2 teaspoon) water for the 15-milligram tablet, or 5 mL (1 teaspoon) for the 30-milligram tablet. Shake the syringe gently. Give the mixture to make sure all of the medicine is taken.
  • Oral tablet with a feeding tube: Dry your hands before you handle the tablet. Do not crush, chew, break, or cut the tablet.
    • 15-milligram tablet: Place the tablet in the syringe and add 4 mL (1 teaspoon) of water.
    • 30-milligram tablet: Place the tablet in the syringe and add 10 mL (2 teaspoons) of water.
    • Shake the syringe gently until the tablet dissolves and is mixed well.
    • Inject or pour the mixture into the feeding tube within 15 minutes.
    • Refill the syringe with 5 mL (1 teaspoon) of water and shake it gently. Flush the tube with the water to rinse all of the medicine from the tube into the stomach.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are also using ampicillin, atazanavir (Reyataz®), digoxin (Lanoxin®), ketoconazole (Nizoral®), sucralfate (Carafate®), tacrolimus (Prograf®), or theophylline (Theo-Dur®). Tell your doctor if you use a blood thinner, such as warfarin or Coumadin®, or an iron supplement, such as ferrous sulfate or ferric gluconate.
  • Make sure your doctor knows if you are also using a diuretic (water pill, such as bumetanide, chlorothiazide, ethacrynic acid, furosemide, hydrochlorothiazide (HCTZ), indapamide, metolazone, torsemide, Bumex®, Demadex®, Diuril®, Edecrin®, Lasix®, Lozol®, or Zaroxolyn®), or certain medicines to treat high blood pressure (such as atenolol, enalapril, lisinopril, losartan, metoprolol, olmesartan, valsartan, Accupril®, Cozaar®, Diovan®, Lotrel®, Toprol®, or Zestril®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, osteoporosis, seizures, or a history of low magnesium levels in your blood.
  • Tell your doctor if you have phenylketonuria (PKU). The tablet form of this medicine contains phenylalanine (aspartame), which can make this condition worse.
  • This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you take this medicine longer than 1 year, or if you take it with digoxin or certain diuretics (water pills). Stop using this medicine and tell your doctor right away if you have seizures, dizziness, a fast or pounding heartbeat, or muscle spasms.
  • Tell your doctor right away if you have diarrhea that does not go away, stomach pain, and fever while taking this medicine.
  • You may be at risk for Clostridium difficile colitis (also called C diff) if you take this medicine. C diff is an inflammation of your large intestine that causes diarrhea. You have a higher risk of this condition if you are also using antibiotics, are elderly, or have other health conditions.Ask your doctor before you take any medicine to stop severe diarrhea.
  • This medicine may increase your risk of broken bones in the hip, wrist, and spine. This is more likely if you are older than 50, if you receive high doses of this medicine, or you use it for longer than 1 year.
  • This medicine is sometimes given together with other medicines to treat ulcers. Make sure you understand how to use the combination of medicines.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.You may need blood or other lab tests to check for unwanted effects.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Fast or uneven heartbeat
  • Seizures, muscle spasms, or tremors
  • Severe diarrhea that does not go away, stomach pain, and fever

If you notice these less serious side effects, talk with your doctor:

  • Constipation, diarrhea, nausea, or stomach pain
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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