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Conjugated estrogens (Vaginal)

Conjugated Estrogens (KON-joo-gay-ted ES-troe-jenz)

Treats vaginal dryness, itching, and burning caused by low estrogen levels or menopause. Also treats vaginal pain during sexual intercourse.

Brand Name(s):

Premarin Vaginal

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to estrogens, or if you are pregnant or have unusual vaginal bleeding. Do not use this medicine if you have liver disease, breast cancer, a problem with blood clotting, or a history of blood clots, heart attack, or stroke.

How to Use This Medicine:

Cream

  • Take your medicine as directed.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Wash your hands with soap and water before and after using this medicine.
  • This medicine is to be used only in the vagina. Use at bedtime unless your doctor tells you otherwise.
  • Wash the applicator with mild soap and water. Do not use hot water.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine applicator(s), containers and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using carbamazepine (Tegretol®), clarithromycin (Biaxin®), erythromycin (Ery-Tab®), itraconazole (Sporanox®), ketoconazole (Nizoral®), phenobarbital (Luminal®), rifampin (Rifadin®, Rimactane®), ritonavir (Norvir®), St. John's wort, or thyroid medicines.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
  • Avoid using douches or other vaginal products unless your doctor tells you to.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you are breastfeeding, have endometriosis, or a history of cancer. Tell your doctor if you have kidney disease, inherited angioedema (swelling of the face, tongue, or throat), asthma, bone disease, diabetes, epilepsy, lupus, migraine headaches, porphyria, thyroid problems, a history of liver problems, or a family history of breast cancer or high cholesterol. Tell your doctor if you have heart disease, high blood pressure, or high or low calcium in the blood.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to be on bedrest. This medicine may affect the results of certain medical tests.
  • Your risk of heart attack, stroke, blood clots, or dementia may increase while using this medicine. Talk with your doctor about this risk. Your risk of blood clots or stroke from this medicine is higher if you smoke. Your risk is also increased if you have diabetes or high cholesterol, or if you are overweight.
  • Long-term use of large doses of estrogens may increase your risk of some kinds of cancer, including breast cancer and cancer of the uterus. Check with your doctor right away if you have unusual vaginal bleeding. Ask your doctor if you have questions about your personal risks compared with the benefits of this medicine.
  • Tell your doctor if you have a severe headache or vision changes with this medicine. Your doctor may want you to have your eyes checked by an eye doctor.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Breast lumps
  • Chest pain, shortness of breath, or coughing up blood
  • Confusion or memory problems
  • Numbness or weakness in your arm or leg, or on one side of your body
  • Pain in your lower leg (calf)
  • Problems with vision, speech, or walking
  • Rapid weight gain
  • Sudden and severe stomach pain, with or without nausea, vomiting, fever, and lightheadedness
  • Sudden or severe headache
  • Swelling in your hands, ankles, or feet
  • Unusual vaginal bleeding or discharge
  • Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

  • Breast pain or tenderness
  • Diarrhea, bloating, or stomach cramps or pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 4/4/2014

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