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Carisoprodol/aspirin/codeine (By mouth)

Aspirin (AS-pir-in), Carisoprodol (kar-eye-soe-PROE-dol), Codeine (KOE-deen)

Relieves muscle pain and stiffness. This medicine contains a muscle relaxer, a nonsteroidal anti-inflammatory drug (NSAID), and a narcotic pain reliever.

Brand Name(s):

Soma Compound w/Codeine

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

Do not use this medicine if you have had an allergic reaction to carisoprodol, codeine, aspirin, or meprobamate. Do not use this medicine if you are pregnant or breastfeeding, or if you have had stomach or bowel problems (such as blockage, perforation) caused by aspirin, porphyria, or a history of asthma with nasal polyps and rhinitis. This medicine is not meant for use in children. Serious breathing problems and deaths have occurred when children have been given medicine that contains codeine.

How to Use This Medicine:


  • Take your medicine as directed.
  • It is best to take this medicine with food or milk.
  • Drink plenty of liquids to help avoid constipation.
  • This medicine is not for long-term use.Do not use the medicine for more than 2 to 3 weeks (14 to 21 days) to treat pain unless your doctor has told you to.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using St John's wort, fluvoxamine (Luvox®), omeprazole (Prilosec®), or rifampin (Rifadin®, Rimactane®). Tell your doctor if you are also using medicine to lower blood pressure (such as atenolol, benazepril, enalapril, hydrochlorothiazide, lisinopril, metoprolol, propranolol, Avalide®, Avapro®, Benicar®, Bystolic®, Cozaar®, Diovan®, Lotrel®, Micardis®, Tenormin®, Vasotec®, Zestoretic®, Zestril®), an NSAID pain or arthritis medicine (such as diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or insulin or diabetes medicine that you take by mouth (such as glimepiride, glipizide, glyburide, metformin, Actos®, Amaryl®, Janumet®, Januvia®).
  • Make sure your doctor knows if you are also using acetazolamide (Diamox®), methotrexate (Folex®, Rheumatrex®), probenecid (Benemid®), sulfinpyrazone (Anturane®), antacid or stomach medicine (including ranitidine, sucralfate, Carafate®, Pepcid®, Tagamet®, Zantac®), a blood thinner (such as clopidogrel, heparin, warfarin, Coumadin®, Jantoven®), a steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®), a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®), or medicine to treat depression (such as amitriptyline, nortriptyline, Elavil®).
  • Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
  • Do not drink alcohol while you are using this medicine.Tell your doctor if you usually drink 3 or more alcoholic beverages per day.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Make sure your doctor knows if you have kidney disease, liver disease, or digestive system problems (such as pancreas problems or stomach ulcers). Tell your doctor if you have lung disease or breathing problems (such as COPD, asthma, or sleep apnea) or a history of head injury. Tell your doctor if you have been addicted to drugs or alcohol.
  • Aspirin should not be given to children or teenagers who have chickenpox or flu symptoms, unless approved by your child's doctor.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • This medicine may make you dizzy, drowsy, or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • When a mother is breastfeeding and takes codeine, there is a very small chance that this medicine could cause serious side effects in the baby. This is because codeine works differently in a few women, so their breast milk contains too much medicine. If you take codeine, be alert for these signs of overdose in your nursing baby: sleeping more than usual, trouble breastfeeding, trouble breathing, or being limp and weak. Call the baby's doctor right away if you think there is a problem. If you cannot talk to the doctor, take the baby to the emergency room or call 911.
  • This medicine may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (such as a blood thinner or NSAIDs).
  • If you think you or someone else may have taken too much of this medicine, get emergency help at once. Signs of an overdose include seizure; extreme sleepiness; passing out; trouble breathing; uneven, fast, slow, or shallow breathing; nausea; vomiting; confusion; or pinpoint pupils of the eyes.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Call your doctor if your symptoms do not improve or if they get worse.Do not use the medicine for more than 2 to 3 weeks (14 to 21 days) to treat pain unless your doctor has told you to.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloody or black, tarry stools
  • Blue lips, fingernails, or skin
  • Extreme sleepiness or drowsiness, confusion
  • Lightheadedness, dizziness, or fainting
  • Pinpoint pupils of the eyes
  • Ringing in the ears
  • Seizures
  • Severe constipation, stomach pain, nausea
  • Trouble breathing, shallow breathing
  • Vomiting blood or something that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Nausea, vomiting, constipation, heartburn

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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