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Fluconazole (By mouth)

Fluconazole (floo-KON-a-zole)

Prevents and treats fungal infections. Belongs to a class of drugs called antifungals.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to fluconazole.

How to Use This Medicine:

Liquid, Tablet

  • Take your medicine as directed.
  • Oral liquid: Shake well just before each use. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. The oral liquid should be kept in the refrigerator or at room temperature and used within 14 days. Do not freeze.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you also use astemizole, cisapride, pimozide, quinidine, or terfenadine.
  • Some foods and medicines can affect how fluconazole works. Tell your doctor if you are using cimetidine, erythromycin, midazolam, prednisone, rifabutin, rifampin, theophylline, triazolam, vitamin A supplements, or voriconazole. Also tell your doctor if you are using any of the following:
    • A blood thinner (such as warfarin)
    • A diuretic or "water pill" (such as hydrochlorothiazide), or blood pressure medicine (such as amlodipine, felodipine, isradipine, losartan, nifedipine)
    • Cancer medicine (such as cyclophosphamide, vinblastine, vincristine)
    • Diabetes medicine that you take by mouth (such as glipizide, glyburide, tolbutamide)
    • Medicine to lower cholesterol (such as atorvastatin, fluvastatin, simvastatin)
    • Medicine to treat depression (such as amitriptyline, nortriptyline)
    • Medicine to treat HIV/AIDS (such as saquinavir, zidovudine)
    • Medicine to treat seizures (such as carbamazepine, phenytoin)
    • Medicine that weakens the immune system (such as cyclosporine, sirolimus, tacrolimus)
    • Narcotic pain medicine (such as alfentanil, fentanyl, methadone)
    • Pain or arthritis medicine (such as celecoxib, flurbiprofen, ibuprofen, naproxen)

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems, cancer, or HIV/AIDS.
  • This medicine may cause the following problems:
    • Changes in heart rhythm, such as a condition called QT prolongation
    • Liver problems
    • Serious skin reactions
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Fast, pounding, or uneven heartbeat
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea, stomach pain, or diarrhea
  • Mild skin rash

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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