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Betamethasone/clotrimazole (On the skin)

Betamethasone Dipropionate (bay-ta-METH-a-sone dye-PROE-pee-oh-nate), Clotrimazole (kloe-TRIM-a-zole)

Treats athlete's foot, ringworm, and other fungus infections. Betamethasone is a steroid. Clotrimazole is an antifungal agent.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to clotrimazole or similar drugs, such as butoconazole (Gynazole®), miconazole (Monistat®), econazole (Spectazole®), or ketoconazole (Nizoral®). Also avoid using the medicine if you have had an allergic reaction to betamethasone or medicines such as hydrocortisone (Hytone®), fluocinonide (Lidex®), or triamcinolone (Aristocort®). This medicine should not be used to treat diaper rash.

How to Use This Medicine:

Cream, Lotion

  • Take your medicine as directed.
  • This medicine is for use on the skin only. Do not get it in your eyes, nose, mouth, or in or around the vagina. Do not use it on skin areas that have cuts or scrapes. If it does get on these areas, rinse it off right away.
  • Wash your hands with soap and water before and after you use this medicine.
  • Apply a thin layer of the medicine to the affected area. Rub it in gently.
  • Shake the bottle of lotion well just before using.
  • Do not cover the treated area with a bandage unless directed by your doctor.Wear loose-fitting clothes if you are using this medicine to treat an infection in the groin area.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

If a dose is missed:

  • Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the lotion bottle upright, not laying on its side.
  • Ask your pharmacist or doctor how to dispose of the medicine container and any leftover or expired medicine.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Before using this medicine, make sure your doctor knows if you are using other medicines on your skin, or if you are using any steroid medicines.
  • Do not put cosmetics or skin care products on the treated skin.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have an active infection of the skin, such as herpes or chickenpox.
  • Tell your doctor if you have diabetes. This medicine may raise the levels of sugar in your blood or urine.
  • Do not give this medicine to your child unless your doctor tells you to. Children may be more likely to have serious side effects from this medicine.
  • Do not use this medicine to treat a skin problem your doctor has not examined.
  • If your symptoms do not improve after 1 or 2 weeks of treatment with this medicine, or if they get worse, check with your doctor. This medicine should not be used for a long time.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe itching, burning, or skin irritation.
  • Signs of infection such as redness, swelling, drainage, or pus.

If you notice these less serious side effects, talk with your doctor:

  • Irritation, burning, redness, peeling, or blistering of the skin.
  • Mild, temporary stinging.
  • Numbness or tingling at the site of application.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/4/2014

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