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Isosorbide dinitrate (By mouth)

Isosorbide Dinitrate (eye-soe-SOR-bide dye-NYE-trate)

Treats and prevents angina (chest pain). This medicine is a nitrate.

Brand Name(s):

Dilatrate-SR, Isordil Titradose

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to isosorbide or nitrates.

How to Use This Medicine:

Tablet, Long Acting Capsule, Long Acting Tablet, Chewable Tablet

  • Take your medicine as directed.
  • Extended-release tablet or capsule: Swallow the tablet or capsule whole. Do not break, crush, or chew it.
  • Sublingual tablet: Sit down while you take this medicine. Wet the tablet with water. Place it under your tongue and let it dissolve. Do not chew, crush, or swallow the tablet whole. Do not eat, drink, or smoke while the tablet is dissolving. If your chest pain lasts longer than 5 minutes, put a second tablet under your tongue. If the pain lasts another 5 minutes, use a third tablet. If your pain does not go away after the third dose, call your doctor and have someone take you to a hospital.
  • Missed dose: If you miss a dose or forget to use your medicine, use it as soon as you can. If your next regular dose is less than 2 hours away, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how isosorbide dinitrate works. Tell your doctor if you use medicine for erectile dysfunction, such as sildenafil.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have low blood pressure, heart failure, an enlarged heart, or other heart problems.
  • Medicines that treat chest pain sometimes cause headaches. These headaches are a sign that the medicine is working. Do not stop taking the medicine or change the time you take it to avoid the headaches. You may take aspirin or acetaminophen to relieve your pain. Tell your doctor if your headache pain is severe.
  • This medicine could cause you to feel dizzy or lightheaded. This is more likely to happen if you drink alcohol or are dehydrated. Stand up slowly to help prevent dizziness.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips or fingernails, trouble breathing
  • Lightheadedness, dizziness, fainting
  • Slow heartbeat, increased chest pain
  • Throbbing or severe headache, confusion, fever, trouble seeing

If you notice these less serious side effects, talk with your doctor:

  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 11/4/2014
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