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Measles, mumps, rubella, and varicella virus vaccine live (Subcutaneous route)

Pronunciation:

MEE-zuls VYE-rus VAX-een, lyve, mumps VYE-rus VAX-een, lyve, roo-BELL-a VYE-rus VAX-een, lyve, var-i-SEL-a VYE-rus VAX-een

Brand Names:

  • ProQuad

Dosage Forms:

  • Powder for Solution
  • Powder for Suspension

Classifications:

Therapeutic—

Vaccine

Uses of This Medicine:

Measles, mumps, rubella, and varicella virus vaccine (live) is an active immunizing agent that is given to protect against infections caused by measles (rubeola), mumps, rubella (German measles), and varicella (chickenpox) viruses. The combination vaccine works by causing the body to produce its own protection (antibodies) against these diseases.

Measles (also known as coughing measles, hard measles, morbilli, red measles, rubeola, and 10-day measles) is an infection that is easily spread from one person to another. Infection with measles can cause serious problems, such as stomach problems, pneumonia, ear infections, sinus problems, convulsions (seizures), brain damage, and possibly death. The risk of serious complications and death is greater for adults and infants than for children and teenagers.

Mumps is an infection that can cause serious problems, such as encephalitis and meningitis, which affect the brain. In addition, teenage boys and men are very susceptible to a condition called orchitis, which causes pain and swelling in the testicles and scrotum, and in rare cases, sterility. Also, mumps infection can cause spontaneous abortion (miscarriage) in women during the first 3 months of pregnancy.

Rubella (also known as German measles) is a serious infection that causes miscarriages, stillbirths, or birth defects in unborn babies when pregnant women get the disease.

Varicella (commonly known as chickenpox) is an infection that is easily spread from one person to another. Chickenpox is usually a mild infection but sometimes it can cause serious problems, such as pneumonia, inflammation of the brain, and a rare disease called Reye's syndrome.

Immunization against measles, mumps, german measles, and chickenpox is recommended for children 12 months to 12 years of age who has not had these diseases. Immunization against these diseases is not recommended for infants younger than 12 months of age and for children 13 years of age and older.

This vaccine is to be administered only by or under the supervision of your child’s doctor or other authorized healthcare professional.

Before Using This Medicine:

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of measles, mumps, rubella, and varicella virus vaccine in children 12 months to 12 years of age. However, this vaccine is not recommended for infants younger than 12 months of age and for children 13 years of age and older.

Older adults—

This vaccine is not recommended for use in adult patients.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this vaccine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Receiving this vaccine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aclarubicin
  • Adalimumab
  • Aldesleukin
  • Alemtuzumab
  • Altretamine
  • Amonafide
  • Amsacrine
  • Asparaginase
  • Aspirin
  • Azacitidine
  • Azathioprine
  • Benorilate
  • Bleomycin
  • Broxuridine
  • Busulfan
  • Capecitabine
  • Carboplatin
  • Carmustine
  • Certolizumab Pegol
  • Chlorambucil
  • Choline Magnesium Trisalicylate
  • Cisplatin
  • Cladribine
  • Cyclophosphamide
  • Cytarabine
  • Cytarabine Liposome
  • Dacarbazine
  • Dactinomycin
  • Daunorubicin
  • Daunorubicin Citrate Liposome
  • Decitabine
  • Docetaxel
  • Doxifluridine
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Edatrexate
  • Eflornithine
  • Epirubicin
  • Estramustine
  • Etanercept
  • Etoposide
  • Everolimus
  • Fingolimod
  • Floxuridine
  • Fludarabine
  • Fluorouracil
  • Fotemustine
  • Gallium Nitrate
  • Gemcitabine
  • Golimumab
  • Hydroxyurea
  • Idarubicin
  • Ifosfamide
  • Infliximab
  • Irinotecan
  • Lomustine
  • Mechlorethamine
  • Melphalan
  • Meningococcal Vaccine
  • Mercaptopurine
  • Mesalamine
  • Methotrexate
  • Mitolactol
  • Mitomycin
  • Mitotane
  • Mitoxantrone
  • Mycophenolic Acid
  • Olsalazine
  • Oxaliplatin
  • Paclitaxel
  • Pegaspargase
  • Pentostatin
  • Pipobroman
  • Pirarubicin
  • Plicamycin
  • Pneumococcal Vaccine Polyvalent
  • Procarbazine
  • Raltitrexed
  • Rilonacept
  • Rituximab
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Sirolimus
  • Sodium Salicylate
  • Sodium Thiosalicylate
  • Streptozocin
  • Tacrolimus
  • Teceleukin
  • Tegafur
  • Temsirolimus
  • Teniposide
  • Thioguanine
  • Thiotepa
  • Topotecan
  • Trabectedin
  • Treosulfan
  • Trimetrexate
  • Trofosfamide
  • Trolamine Salicylate
  • Uracil Mustard
  • Ustekinumab
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vindesine
  • Vinorelbine

Receiving this vaccine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abatacept
  • Leflunomide

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood disorder (weak immune system) or
  • Bone marrow cancer or
  • Immune deficiency condition, or family history of or
  • Illness with a fever or
  • Leukemia (cancer of the blood) or
  • Lymphoma (cancer of the immune system) or
  • Receiving immunosuppressive therapy or
  • Tuberculosis, active and untreated—Should not be used in patients with these conditions.
  • Brain injury or
  • Seizures, history of or
  • Thrombocytopenia (not enough platelets in the blood) or history of—Use with caution. May make these conditions worse.

Proper Use of This Medicine:

A nurse or other trained health professional will give your child this vaccine. This vaccine is given as a shot under your skin (usually in the upper arms or thighs).

Your child should receive one shot of the vaccine at 12 to 15 months of age and possibly a second shot at 4 to 6 years of age.

Your child may receive certain other vaccines at the same time as this one, but in a different body area.

You should receive a patient information sheet about all of the vaccines your child receives. Make sure you understand all of the information that is given to you.

It is important to receive this vaccine at the proper time. If your child misses a scheduled shot, call your child's doctor to make another appointment as soon as possible.

Precautions While Using This Medicine:

It is very important that your child return to your doctor’s office at the right time if your child needs a second dose of the vaccine. Be sure to notify your doctor of any side effects that occur after your child receive this vaccine.

Do not become pregnant for 3 months after receiving this vaccine without first checking with your doctor. There is a chance that this vaccine may cause problems during pregnancy. If you think you have become pregnant, tell your doctor right away. Your doctor may want you to join a pregnancy registry for patients receiving this vaccine.

Children who have received this vaccine have developed a fever and in some cases a fever with seizures. Talk with your child's doctor if you have concerns about this.

Your child should avoid close contact with people at high risk for catching the varicella virus for 6 weeks after receiving this vaccine. People who are at risk for catching the virus are pregnant women, newborn babies, and anyone who has a weak immune system that keeps them from fighting infections.

Tell your doctor that you have received this vaccine:

  • If you are to receive blood transfusions or other blood products within 3 months of receiving this vaccine.
  • If you are to receive varicella-zoster immune globulin (VZIG) or other immune globulins within 3 to 5 months after receiving this vaccine.
  • If you are to have a tuberculin skin test within 4 to 6 weeks after receiving this vaccine.
  • If you are to receive any other live virus vaccines within 1 or 3 months of receiving this vaccine.

Do not take aspirin or medicines that contain aspirin (such as cold medicines) for 6 weeks after receiving this vaccine. Carefully check the label of any pain, headache, or cold medicine you give to your child to be sure it does not contain aspirin or salicylic acid.

This vaccine contains albumin, which comes from human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your child's doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Fever over 39 °C (102 °F)
Less common
Body aches or pain
chills
cough
ear congestion
fever
headache
loss of voice
nasal congestion
rash that looks like chickenpox or measles
runny nose
sneezing
sore throat
unusual tiredness or weakness
Incidence not known
Agitation
back pain, sudden and severe
bleeding gums
blistering, peeling, or loosening of the skin
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine or stools
bloody nose
bloody or black, tarry stools
blurred vision
burning or stinging of the skin
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain
coma
confusion
cough or hoarseness
cough producing mucus
diarrhea
difficulty with breathing
difficulty with swallowing
dizziness
drowsiness
fainting
fast heartbeat
general feeling of discomfort or illness
hallucinations
hives
inability to move the arms and legs
inability to speak
irritability
itching, pain, redness, swelling, tenderness, or warmth on the skin
joint or muscle pain
large, flat, blue, or purplish patches in the skin
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
lower back or side pain
mood or mental changes
muscle aches and pains
muscle weakness, sudden and progressing
nausea
noisy breathing
numbness, tingling, pain, or weakness in the hands or feet
pain, numbness, or tingling of the hands, arms, legs, or feet
pain, tenderness, or swelling in the testicles and scrotum
painful blisters on the trunk of the body
painful cold sores or blisters on the lips, nose, eyes, or genitals
painful knees and ankles
painful or difficult urination
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
raised red swellings on the skin, buttocks, legs, or ankles
rapid weight gain
red skin lesions, often with a purple center
red, irritated eyes
seizures
severe or sudden headache
shakiness and unsteady walk
shakiness in the legs, arms, hands, or feet
shivering
shortness of breath
skin rash
skin rash on the face, scalp, or stomach
slurred speech
sores, ulcers, or white spots on the lips or in the mouth
stiff neck or back
stomach pain
sudden numbness and weakness in the arms and legs
sweating
swelling or puffiness of the face
swollen or painful glands
swollen, painful, or tender lymph glands in the neck, armpit, or groin
swollen, painful, or tender lymph glands on the side of the face or neck
temporary blindness
tenderness
thickening of bronchial secretions
tightness in the chest
tingling of the hands or feet
trembling or shaking of the hands or feet
trouble sleeping
unsteadiness, trembling, or other problems with muscle control or coordination
unusual bleeding or bruising
unusual weight gain or loss
vomiting
warmth on the skin
weakness in the arm or leg on one side of the body, sudden and severe
weakness of the muscles in your face
wheezing
white patches in the mouth or throat or on the tongue
white patches with diaper rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Incidence not known
Abnormal dreams
blindness
bloated
blue-yellow color blindness
deafness
decreased vision
difficulty with moving
double vision
ear pain
excess air or gas in the stomach or intestines
eye pain
full feeling
irritation and swelling of the eyelids
lack of feeling or emotion
muscle or bone pain
muscle pain or stiffness
nervousness
pain and swelling in the scrotum
pain in the hip, leg, or neck
pain or tenderness around the eyes and cheekbones
passing gas
red rash with watery, yellow-colored, or pus filled blisters
thick yellow to honey-colored crusts
uncaring
unusually deep sleep
unusually long duration of sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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