Skip to main content

Morphine (Epidural route)

Pronunciation:

MOR-feen SUL-fate LYE-poh-some

Brand Names:

  • DepoDur

Dosage Forms:

  • Suspension, Extended Release

Classifications:

Therapeutic—

Analgesic

Chemical—

Opioid

Uses of This Medicine:

Morphine epidural injection is used to relieve pain following a major surgery. It is given right before a surgery or during a cesarean section delivery right after the baby's umbilical cord is clamped.

Morphine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

This medicine is available only with your doctor's prescription and will be given by or under the immediate supervision of your doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of morphine epidural injection in the pediatric population. Use of morphine epidural injection is not recommended in children.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of morphine epidural injection in the elderly. However, elderly patients are more likely to have age-related heart, stomach, or lung problems, which may require caution and an adjustment in the dose for patients receiving morphine epidural injection.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Acepromazine
  • Alfentanil
  • Alprazolam
  • Alvimopan
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amobarbital
  • Amoxapine
  • Anileridine
  • Aripiprazole
  • Asenapine
  • Atropine
  • Azithromycin
  • Baclofen
  • Belladonna
  • Benperidol
  • Benztropine
  • Biperiden
  • Bosutinib
  • Brofaromine
  • Bromazepam
  • Brompheniramine
  • Buprenorphine
  • Buspirone
  • Butabarbital
  • Butalbital
  • Butorphanol
  • Captopril
  • Carbinoxamine
  • Carisoprodol
  • Carphenazine
  • Carvedilol
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorpheniramine
  • Chlorpromazine
  • Chlorzoxazone
  • Cimetidine
  • Clarithromycin
  • Clemastine
  • Clidinium
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clorgyline
  • Clozapine
  • Cobicistat
  • Codeine
  • Conivaptan
  • Cyclobenzaprine
  • Cyclopentolate
  • Cyclosporine
  • Cyproheptadine
  • Darifenacin
  • Desipramine
  • Dexmedetomidine
  • Dezocine
  • Diacetylmorphine
  • Diazepam
  • Dichloralphenazone
  • Dicyclomine
  • Difenoxin
  • Dihydrocodeine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenoxylate
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxylamine
  • Dronedarone
  • Droperidol
  • Enflurane
  • Erythromycin
  • Estazolam
  • Eszopiclone
  • Ethchlorvynol
  • Ethopropazine
  • Ethylmorphine
  • Felodipine
  • Fentanyl
  • Fesoterodine
  • Flavoxate
  • Flunitrazepam
  • Fluphenazine
  • Flurazepam
  • Fluspirilene
  • Fospropofol
  • Furazolidone
  • Glycopyrrolate
  • Halazepam
  • Haloperidol
  • Halothane
  • Hexobarbital
  • Homatropine
  • Hydrocodone
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine
  • Imipramine
  • Ipratropium
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Itraconazole
  • Ivacaftor
  • Ketamine
  • Ketazolam
  • Ketobemidone
  • Ketoconazole
  • Lazabemide
  • Levorphanol
  • Linezolid
  • Lomitapide
  • Lopinavir
  • Loratadine
  • Lorazepam
  • Lormetazepam
  • Loxapine
  • Meclizine
  • Medazepam
  • Melperone
  • Mepenzolate
  • Meperidine
  • Mephobarbital
  • Meptazinol
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methdilazine
  • Methocarbamol
  • Methohexital
  • Methotrimeprazine
  • Methylene Blue
  • Methylnaltrexone
  • Midazolam
  • Moclobemide
  • Molindone
  • Moricizine
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Nalmefene
  • Nalorphine
  • Naloxegol
  • Naloxone
  • Nialamide
  • Nicomorphine
  • Nilotinib
  • Nitrazepam
  • Nitrous Oxide
  • Nortriptyline
  • Olanzapine
  • Opium
  • Opium Alkaloids
  • Orphenadrine
  • Oxazepam
  • Oxitropium Bromide
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Papaveretum
  • Paregoric
  • Pargyline
  • Paroxetine
  • Pentazocine
  • Pentobarbital
  • Perazine
  • Periciazine
  • Perphenazine
  • Phenelzine
  • Phenobarbital
  • Pimozide
  • Pipenzolate Bromide
  • Piperacetazine
  • Pipotiazine
  • Pirenzepine
  • Piritramide
  • Prazepam
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Procyclidine
  • Promazine
  • Promethazine
  • Propantheline
  • Propiverine
  • Propofol
  • Propoxyphene
  • Protriptyline
  • Quazepam
  • Quercetin
  • Quetiapine
  • Quinidine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Remoxipride
  • Ritonavir
  • Samidorphan
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Sertindole
  • Simeprevir
  • Sodium Oxybate
  • Solifenacin
  • Stramonium
  • Sufentanil
  • Sulpiride
  • Sunitinib
  • Suvorexant
  • Tapentadol
  • Telaprevir
  • Temazepam
  • Terodiline
  • Thiethylperazine
  • Thiopropazate
  • Thioridazine
  • Thiothixene
  • Ticagrelor
  • Tilidine
  • Tiotropium
  • Tizanidine
  • Tocophersolan
  • Tolonium Chloride
  • Toloxatone
  • Tolterodine
  • Topiramate
  • Tramadol
  • Tranylcypromine
  • Triazolam
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trihexyphenidyl
  • Trimeprazine
  • Trimipramine
  • Tropicamide
  • Umeclidinium
  • Verapamil
  • Zaleplon
  • Zolpidem
  • Zopiclone
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Chloroprocaine
  • Epinephrine
  • Esmolol
  • Gabapentin
  • Lidocaine
  • Perampanel
  • Rifampin
  • Somatostatin
  • Yohimbine

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma, severe or
  • Head injury, suspected or known or
  • Increased pressure in the head or
  • Paralytic ileus (intestine stops working and may be blocked) or
  • Respiratory depression (very slow breathing) or
  • Shock (serious condition with very little blood flow in the body)—Should not be used in patients with these conditions.
  • Breathing problems, severe (e.g., hypoxia, chronic obstructive pulmonary disease, COPD) or
  • Enlarged prostate (BPH, prostatic hypertrophy) or
  • Heart disease or
  • Problems with passing urine—Use with caution. May increase risk for more serious side effects.
  • Gallbladder disease or
  • Hypotension (low blood pressure) or
  • Sleep apnea syndrome (breathing problems during sleep) or
  • Pancreatitis (inflammation of the pancreas) or
  • Seizures, history of—Use with caution. May make these conditions worse.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle or catheter in your back (epidural).

Precautions While Using This Medicine:

It is important that your doctor check your progress after you receive this medicine. This is to make sure that the medicine is working properly, and to allow your doctor to check for any unwanted effects.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the medicines listed above after you receive this medicine.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred vision
confusion
decrease in the frequency of urination
decrease in urine volume
difficulty in passing urine (dribbling)
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
drowsiness
fast, pounding, or irregular heartbeat or pulse
painful urination
pale skin
shortness of breath
sweating
unusual tiredness or weakness
Less common
Abdominal or stomach cramps or pain
bloating
constipation
convulsions
diarrhea
difficult or labored breathing
dry mouth
increased thirst
irregular, fast, slow, or shallow breathing
loss of appetite
mood changes
muscle pain or cramps
pale or blue lips, fingernails, or skin
restlessness
shakiness
sleepiness
slow to respond
slurred speech
tightness in the chest
unconsciousness
vomiting
wheezing
Incidence not known
Bluish lips or skin
disorientation
hallucinations
lethargy
low blood pressure or pulse
severe drowsiness
slowing of the heartbeat
unresponsiveness
very slow breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bloated or full feeling
excess air or gas in the stomach or intestines
fever
headache
nausea
passing gas
skin itching
sleeplessness
trouble sleeping
troubled breathing with exertion
unable to sleep
unusual bleeding or bruising
Less common
Back pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain or discomfort
fear or nervousness
feeling unusually cold
lower abdominal or stomach pain or pressure
pounding in the ears
pressure in the stomach
shivering
slow or irregular heartbeat
swelling of the abdominal or stomach area
Incidence not known
Not alert
trouble with coordination

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

Copyright © 1984- Thomson Micromedex. All rights reserved.

Thomson & A.D.A.M