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Cefoxitin (Intravenous route)

Pronunciation:

sef-OX-i-tin

Brand Names:

  • Mefoxin

Dosage Forms:

  • Powder for Solution
  • Solution

Classifications:

Therapeutic—

Antibiotic

Pharmacologic—

2nd Generation Cephalosporin

Uses of This Medicine:

Cefoxitin injection is used to treat bacterial infections in many different parts of the body. This medicine is also given before certain types of surgery to prevent infections.

Cefoxitin injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of cefoxitin injection in children. However, safety and efficacy have not been established in children younger than 3 months old.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of cefoxitin injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving cefoxitin injection.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Colitis (inflammation in gut), history of or
  • Diarrhea, severe, history of or
  • Seizures—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

Precautions While Using This Medicine:

If your symptoms or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Cefoxitin injection may cause diarrhea, and in some cases it can be severe. Do not take any medicine or give medicine to your child to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you or your child have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Changes in skin color
pain
swelling of the foot or leg
tenderness
Rare
Agitation
coma
confusion
decreased urine output
depression
dizziness
headache
hostility
irritability
lethargy
muscle twitching
nausea
rapid weight gain
seizures
stupor
swelling of the face, ankles, or hands
unusual tiredness or weakness
Incidence not known
Abdominal or stomach cramps or tenderness
back, leg, or stomach pains
bleeding and bruising
bleeding gums
blistering, peeling, or loosening of the skin
bloating
bloody or cloudy urine
bloody, black, or tarry stools
chest pain
chills
clay-colored stools
cloudy urine
cough
coughing up blood
cracks in the skin
dark urine
decrease in urine output or decrease in urine-concentrating ability
diarrhea
diarrhea, watery and severe, which may also be bloody
difficult or labored breathing
difficult or painful urination
difficulty with breathing, chewing, swallowing, or talking
dizziness
double vision
drooping eyelids
fast heartbeat
feeling of discomfort
fever
general body swelling
greatly decreased frequency of urination or amount of urine
headache
high fever
hives
increased menstrual flow or vaginal bleeding
increased thirst
inflammation of the joints
itching
itching of the vagina or genital area
joint or muscle pain
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
loss of heat from the body
muscle aches
muscle weakness
nosebleeds
pain during sexual intercourse
pale skin
paralysis
prolonged bleeding from cuts
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
red or black, tarry stools
red or dark brown urine
red skin lesions, often with a purple center
red, irritated eyes
red, swollen skin
scaly skin
severe tiredness
shortness of breath
sore throat
sores, ulcers, or white spots on the lips or in the mouth
sudden decrease in the amount of urine
swelling of the feet or lower legs
swollen lymph glands
swollen or painful glands
thick, white vaginal discharge with no odor or with a mild odor
tightness in the chest
troubled breathing with exertion
unexplained bleeding or bruising
unpleasant breath odor
unusual bleeding or bruising
unusual weight loss
vomiting
vomiting of blood
wheezing
yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Red streaks on the skin
swelling, tenderness, or pain at the injection site
Incidence not known
Hives or welts
redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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