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Ceftriaxone (Injection route)

Pronunciation:

sef-trye-AX-one

Brand Names:

  • Rocephin

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Antibiotic

Pharmacologic—

3rd Generation Cephalosporin

Uses of This Medicine:

Ceftriaxone is used to treat bacterial infections in many different parts of the body. This medicine is also given before certain types of surgery to prevent infections.

Ceftriaxone belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ceftriaxone in children. Because of ceftriaxone's toxicity, use in newborn and premature babies is not recommended.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ceftriaxone in the elderly.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Calcium Acetate
  • Calcium Chloride
  • Calcium Gluceptate
  • Calcium Gluconate
  • Lactated Ringer's Solution
  • Ringer's Solution

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Warfarin

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Diarrhea or
  • Gallbladder disease or
  • Pancreatitis (inflammation of the pancreas) or
  • Stomach or bowel disease (e.g., colitis), history of—Use with caution. May make these conditions worse.
  • Hyperbilirubinemia (high bilirubin in the blood)—Should not be used in newborn (less than 28 days of age) and premature infants with this condition.
  • Kidney disease or
  • Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.
  • Liver disease, severe or
  • Undernourished condition—May be worsened by ceftriaxone and you may need to take Vitamin K.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles or through a needle placed in one of your veins.

Precautions While Using This Medicine:

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.

Ceftriaxone may cause diarrhea, and in some cases it can be severe. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Pancreatitis may occur while you are using this medicine. Tell your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Do not take other medicines unless they have been discussed with your doctor. This includes calcium-containing solutions for injection, prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Black, tarry stools
chest pain
chills
cough
fever
painful or difficult urination
shortness of breath
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swollen glands
unusual bleeding or bruising
unusual tiredness or weakness
Less common
Diarrhea
Rare
Abdominal or stomach cramps or tenderness
back, leg, or stomach pains
bleeding gums
bloating
blood in the urine or stools
bloody nose
bluish color
changes in skin color
clay-colored stools
convulsions
cough or hoarseness
dark urine
diarrhea, watery and severe, which may also be bloody
difficulty with breathing
difficulty with swallowing
dizziness
fast, irregular, pounding, or racing heartbeat or pulse
feeling of discomfort
feeling of warmth
fever with or without chills
general body swelling
general feeling of tiredness or weakness
headache
hives
increased sweating
increased thirst
inflammation of the joints
itching
loss of appetite
lower back or side pain
muscle aches
nausea or vomiting
noisy breathing
nosebleeds
pain
pale skin
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
rash
redness of the face, neck, arms, and occasionally, upper chest
shortness of breath
skin rash
swelling of the foot or leg
swollen lymph glands
tenderness
tightness in the chest
troubled breathing with exertion
unpleasant breath odor
unusual weight loss
vomiting of blood
watery or bloody diarrhea
wheezing
yellowing of the eyes or skin
Incidence not known
Blistering, peeling, or loosening of the skin
chest pain
coughing up blood
decrease in the amount of urine
excessive muscle tone
increased menstrual flow or vaginal bleeding
muscle stiffness, tension, or tightness
nosebleeds
paralysis
prolonged bleeding from cuts
red irritated eyes
red or black, tarry stools
red or dark brown urine
red skin lesions, often with a purple center
restlessness
skin rash with a general disease
swelling
trouble sitting still
unpleasant breath odor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare
Acid or sour stomach
belching
bloated
change in taste
dizziness
excess air or gas in the stomach or intestines
full feeling
headache
heartburn
indigestion
itching of the vagina or genital area
loss of taste
pain during sexual intercourse
passing gas
stomach discomfort, upset, or pain
thick, white vaginal discharge with no odor or with a mild odor
Incidence not known
Hives or welts
redness, swelling, or soreness of the tongue
swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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