Haloperidol (Intramuscular route)
- Haldol Decanoate
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Haloperidol injection is not approved for the treatment of patients with dementia-related psychosis .Intramuscular route(Injectable)
Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Haloperidol decanoate is not approved for the treatment of patients with dementia-related psychosis .
Uses of This Medicine:
Haloperidol injection is used to treat nervous, emotional, and mental conditions (e.g., schizophrenia). It is also used to control the symptoms of Tourette's disorder. This medicine should not be used to treat behavior problems in older adult patients who have dementia.
This medicine is available only with your doctor's prescription.
Before Using This Medicine:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of haloperidol injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of haloperidol injection in the elderly. However, elderly women are more likely to have a side effect called tardive dyskinesia, and elderly patients are more likely to have age-related heart problems, which may require an adjustment in the dose for patients receiving haloperidol injection.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
- Chloral Hydrate
- Eslicarbazepine Acetate
- Morphine Sulfate Liposome
- Perflutren Lipid Microsphere
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Betel Nut
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Other medical problems—
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Breast cancer, prolactin-dependent, history of or
- Chest pain or
- Heart or blood vessel disease, severe or
- Hyperprolactinemia (high prolactin in the blood) or
- Hypotension (low blood pressure) or
- Mania or
- Neuroleptic malignant syndrome, history of or
- Seizures or epilepsy, history of—Use with caution. May make these conditions worse.
- Central nervous system depression, severe or
- Coma or
- Dementia in the elderly or
- Parkinson's disease—Should not be used in patients with these conditions.
- Heart rhythm problems (e.g., familial long QT-syndrome), history of or
- Hypokalemia (low potassium in the blood) or
- Hypomagnesemia (low magnesium in the blood) or
- Hypothyroidism (underactive thyroid) or
- Lung disease (e.g., bronchopneumonia) or
- Thyrotoxicosis (overactive thyroid)—May increase risk for more serious side effects.
Proper Use of This Medicine:
A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles.
Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
Precautions While Using This Medicine:
It is very important that your doctor check your progress while you receive this medicine to allow for changes in your dose and help reduce any unwanted effects.
Contact your doctor as soon as possible if you have chest pain or discomfort, a fast heartbeat, trouble with breathing, or fever and chills. These may be symptoms of a very serious problem with your heart.
This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while using this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.
Check with your doctor right away if you have any of the following symptoms while receiving this medicine: convulsions (seizures); difficulty with breathing; a fast heartbeat; a high fever; high or low blood pressure; increased sweating; loss of bladder control; severe muscle stiffness; unusually pale skin; or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).
This medicine will often make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are using this medicine, since overheating may result in heat stroke. Also, hot baths or saunas may make you feel dizzy or faint while you are using this medicine.
This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.
Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
Haloperidol injection can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Side Effects of This Medicine:
- Incidence not known
- Abdominal or stomach pain
- black, tarry stools
- bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at injection site
- blurred vision
- chest pain
- clay-colored stools
- cold sweats
- continuing nausea or vomiting
- cool, pale skin
- cough or hoarseness
- dark urine
- decrease in frequency of urination
- decrease in urine volume
- decreased urine output
- difficulty in passing urine (dribbling)
- difficulty with breathing
- difficulty with speaking
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- dry mouth
- eye pain
- false or unusual sense of well-being
- fast, pounding, or irregular heartbeat or pulse
- fever with or without chills
- flushed, dry skin
- fruit-like breath odor
- general feeling of illness
- general feeling of tiredness or weakness
- high fever
- high or low blood pressure
- hot, dry skin
- inability to move the eyes
- inability to sit still
- increase in the frequency of seizures
- increased blinking or spasms of the eyelid
- increased hunger
- increased sweating
- increased thirst
- increased urination
- irregular heartbeat recurrent
- lack of sweating
- lip smacking or puckering
- loss of appetite
- loss of bladder control
- loss of consciousness
- lower back or side pain
- muscle weakness
- muscle pain or cramps
- muscle trembling, jerking, or stiffness
- nausea or vomiting
- need to keep moving
- noisy breathing
- painful or difficult urination
- pale skin
- pounding in the ears
- puffing of the cheeks
- rapid or worm-like movements of the tongue
- severe muscle stiffness
- shortness of breath
- shuffling walk
- slurred speech
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sticking out of the tongue
- stiffness of the limbs
- swelling of the face, ankles, or hands
- swollen glands
- tightness in the chest
- tiredness and weakness
- total body jerking
- trouble with breathing, speaking, or swallowing
- trouble with sleeping
- troubled breathing with exertion
- twisting movements of the body
- uncontrolled chewing movements
- uncontrolled twisting movements of the face, neck, trunk, arms, or legs
- unexplained weight loss
- unpleasant breath odor
- unusual bleeding or bruising
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- unusual facial expressions
- unusual tiredness or weakness
- unusually pale skin
- vomiting of blood
- weakness of the arms and legs
- yellow eyes or skin
- Incidence not known
- Acid or sour stomach
- acne or pimples
- blurred vision or any other change in vision
- decreased interest in sexual intercourse
- decreased vision
- difficulty having a bowel movement (stool)
- disturbed color perception
- double vision
- feeling of constant movement of self or surroundings
- fullness or swelling of the breasts
- halos around lights
- inability to have or keep an erection
- increased in sexual ability, desire, drive, or performance
- increased interest in sexual intercourse
- increased sensitivity of the skin to sunlight
- increased watering of the mouth
- loss in sexual ability, desire, drive, or performance
- loss of hair
- menstrual changes
- night blindness
- overbright appearance of lights
- pain or tenderness of the breasts
- painful or prolonged erection of the penis
- redness or other discoloration of the skin
- sensation of spinning
- severe sunburn
- stomach discomfort, upset, or pain
- swelling of the breasts or breast soreness in both females and males
- tunnel vision
- unable to sleep
- unusual secretion of milk
- weight loss
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Last Updated: 11/4/2014