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Diazepam (Injection route)

Pronunciation:

dye-AZ-e-pam

Brand Names:

  • Valium

Dosage Forms:

  • Solution
  • Emulsion

Classifications:

Therapeutic—

Antianxiety

Pharmacologic—

Benzodiazepine, Long Acting

Uses of This Medicine:

Diazepam injection is used to relieve symptoms of anxiety and alcohol withdrawal. It may also be used to treat certain seizure disorders and help relax muscles or relieve muscle spasm.

This medicine may also be used before a surgery or medical procedure to help relieve stress, nervousness, or anxiety and to reduce memory of the procedure.

Diazepam injection is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of diazepam injection in infants. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of diazepam injection in the elderly. However, difficulty with breathing and heart attack are more likely to occur in the elderly, who are usually more sensitive than younger adults to the effects of diazepam injection. Elderly patients may require a lower dose to help reduce unwanted effects.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast-feeding—

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Amobarbital
  • Anileridine
  • Aprobarbital
  • Buprenorphine
  • Butabarbital
  • Butalbital
  • Carbinoxamine
  • Carisoprodol
  • Chloral Hydrate
  • Chlorzoxazone
  • Codeine
  • Dantrolene
  • Eslicarbazepine Acetate
  • Ethchlorvynol
  • Etravirine
  • Fentanyl
  • Fospropofol
  • Hydrocodone
  • Hydromorphone
  • Itraconazole
  • Ketorolac
  • Levorphanol
  • Meclizine
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methocarbamol
  • Methohexital
  • Morphine
  • Morphine Sulfate Liposome
  • Orlistat
  • Oxycodone
  • Oxymorphone
  • Pentobarbital
  • Phenobarbital
  • Primidone
  • Propoxyphene
  • Remifentanil
  • Secobarbital
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Thiopental
  • Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amitriptyline
  • Amprenavir
  • Clarithromycin
  • Dalfopristin
  • Disulfiram
  • Erythromycin
  • Fluvoxamine
  • Fosphenytoin
  • Ginkgo
  • Isoniazid
  • Mirtazapine
  • Perampanel
  • Phenytoin
  • Quinupristin
  • Rifapentine
  • Roxithromycin
  • St John's Wort
  • Theophylline
  • Troleandomycin

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Drug abuse or dependence (or history of)—Dependence on diazepam injection may develop.
  • Alcohol intoxication or
  • Glaucoma or
  • Shock—Should not be used in patients with these conditions.
  • Breathing problems or lung disease
  • Heart or blood vessel disease or
  • Hypotension (low blood pressure) or
  • Muscle weakness—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins or as a shot into one of your muscles.

Your doctor may give you or your child a few doses of this medicine until your condition improves, and then you or your child may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using This Medicine:

It is very important that your doctor check the progress of you or your child at regular visits to see if the medicine is working properly. Blood tests may be needed to check for any unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause some people, especially older persons, to become drowsy, dizzy, lightheaded, clumsy or unsteady, or less alert than they are normally. Also, this medicine may cause double vision or other vision problems. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you or your child stop taking this medicine. Check with your doctor before taking any of the above while you or your child are using this medicine.

Do not stop taking it without checking with your doctor first. Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Shakiness and unsteady walk
tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area
unsteadiness, trembling, or other problems with muscle control or coordination
Less common
Abdominal or stomach pain
black, tarry stools
blurred vision
changes in patterns and rhythms of speech
chest pain or discomfort
chills
cold, clammy, or pale skin
confusion
cough
dark urine
decrease in frequency of urination
decrease in urine volume
difficulty in passing urine (dribbling)
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
fear or nervousness
fever
hallucinations
headache
irregular heartbeats
itching
loss of appetite
loss of bladder control
lower back or side pain
muscle spasm
nausea
nightmares
outbursts of anger
painful or difficult urination
pale skin
rash
shakiness in the legs, arms, hands, or feet
shortness of breath
sleeplessness
slow heart rate
slow or irregular heartbeat
slurred speech
sore throat
sweating
trembling or shaking of hands or feet
trouble in speaking
trouble sleeping
ulcers, sores, or white spots in the mouth
unable to sleep
unpleasant breath odor
unusual bleeding or bruising
unusual excitement, nervousness, restlessness, or irritability
unusual tiredness or weakness
vomiting of blood
yellow eyes or skin
Incidence not known
Deep or fast breathing with dizziness
difficult or troubled breathing
irregular, fast or slow, or shallow breathing
numbness of the feet, hands, and around the mouth
pale or blue lips, fingernails, or skin
tightness in the chest
wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
Change in consciousness
lack of coordination
loss of consciousness
sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
Constipation
decreased interest in sexual intercourse
difficulty in swallowing
discouragement
double vision
dry mouth
feeling of constant movement of self or surroundings
feeling sad or empty
hiccups
hives or welts
inability to have or keep an erection
increase in sexual ability, desire, drive, or performance
increased interest in sexual intercourse
increased watering of the mouth
itching
lack of appetite
loss in sexual ability, desire, drive, or performance
loss of interest or pleasure
redness of skin
seeing double
sensation of spinning
trouble concentrating
uncontrolled eye movements

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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