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Chlorothiazide (Intravenous route)

Pronunciation:

klor-oh-THYE-a-zide

Brand Names:

  • Diuril Sodium
  • Sodium Diuril

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Cardiovascular Agent

Pharmacologic—

Diuretic

Chemical—

Thiazide

Uses of This Medicine:

Chlorothiazide is used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or from treatment with a steroid or hormone medicine.

Chlorothiazide is a thiazide diuretic. It reduces the amount of water in the body by increasing the flow of urine, which helps reduce fluid retention (edema).

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of chlorothiazide in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of chlorothiazide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving chlorothiazide.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Arsenic Trioxide
  • Bepridil
  • Deslanoside
  • Digitalis
  • Digitoxin
  • Digoxin
  • Dofetilide
  • Flecainide
  • Ketanserin
  • Lithium
  • Metildigoxin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Benazepril
  • Bromfenac
  • Bufexamac
  • Calcium
  • Captopril
  • Celecoxib
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Enalaprilat
  • Enalapril Maleate
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Ginkgo
  • Gossypol
  • Ibuprofen
  • Ibuprofen Lysine
  • Imidapril
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Trandolapril
  • Valdecoxib
  • Zofenopril

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anuria (not able to form urine)—Should not be used in patients with this condition.
  • Asthma or
  • Diabetes or
  • Gout or
  • Hypercalcemia (high calcium in the blood) or
  • Hyperuricemia (high uric acid in the blood) or
  • Hypochloremia (low chloride in the blood) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hyponatremia (low sodium in the blood) or
  • Hypophosphatemia (low phosphorus in the blood) or
  • Liver disease or
  • Systemic lupus erythematosus—Use with caution. This medicine may make these conditions worse.
  • Kidney disease—Use with caution. The effects of the medicine may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

Precautions While Using This Medicine:

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known
Abdominal or stomach pain
back, leg, or stomach pains
black, tarry stools
bleeding gums
blisters on skin
blood in urine or stools
bloody or cloudy urine
blue lips and fingernails
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain
chills
clay-colored stools
cold sweats
confusion
constipation
cough or hoarseness
coughing that sometimes produces a pink frothy sputum
coughing up blood
darkened urine
decrease in urine output or decrease in urine-concentrating ability
decreased frequency or amount of urine
diarrhea
difficult, fast, or noisy breathing, sometimes with wheezing
difficulty swallowing
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
dry mouth
fast heartbeat
feeling of constant movement of self or surroundings
fever
flushed, dry skin
fruit-like breath odor
general feeling of discomfort or illness
general feeling of tiredness or weakness
headache
hives
increased blood pressure
increased hunger
increased sensitivity of skin to sunlight
increased sweating
increased thirst
increased urination
indigestion
itching
joint pain, stiffness, or swelling
loss of appetite
lower back or side pain
muscle cramps or pain
nausea
nosebleeds
numbness, tingling, pain, or weakness in hands or feet
pain in joints or muscles
painful or difficult urination
pains in stomach, side, or abdomen, possibly radiating to the back
pale skin
pinpoint red spots on skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness or other discoloration of skin
redness, soreness, or itching skin
seizures
sensation of spinning
severe sunburn
shortness of breath
skin rash
sores, ulcers, or white spots on lips or in mouth
sores, welting, or blisters
sugar in the urine
sweating
swelling in legs and ankles
swelling of face, fingers, or lower legs
swollen or painful glands
tenderness of salivary glands
thickening of bronchial secretions
tightness in chest
trembling
troubled breathing
unexplained weight loss
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight loss
vomiting of blood
weight gain
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
Blistering, peeling, or loosening of skin
cracks in the skin
cramping
decreased interest in sexual intercourse
difficulty having a bowel movement (stool)
hair loss, thinning of hair
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
loss of heat from the body
muscle spasm
pinpoint red or purple spots on skin
red, irritated eyes
red, swollen skin
restlessness
scaly skin
weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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