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Neostigmine (Injection route)

Pronunciation:

nee-oh-STIG-meen

Dosage Forms:

  • Solution
  • Injectable

Classifications:

Therapeutic—

Central Nervous System Agent

Pharmacologic—

Cholinesterase Inhibitor

Uses of This Medicine:

Neostigmine injection is used to treat a muscle disease called myasthenia gravis.

Neostigmine injection is also used to prevent or treat certain kidney or intestinal problems. This medicine is also given after surgery to help reverse the effects of certain types of medicines that have been used to relax the muscles.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of neostigmine injection in children. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Bloxiverz™ in children. However, infants and small children may be more sensitive to the effects of this medicine.

Older adults—

No information is available on the relationship of age to the effects of neostigmine injection in geriatric patients.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Bloxiverz™ in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution for patients receiving Bloxiverz™.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acrivastine
  • Bupropion

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Succinylcholine

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma or
  • Bradycardia (slow heartbeat) or
  • Coronary artery disease (heart disease) or
  • Heart attack, recent or
  • Heart rhythm problems or
  • Hypotension (low blood pressure) or
  • Overactive thyroid or
  • Seizures or
  • Stomach ulcer—Use with caution. May make these conditions worse.
  • Intestinal (bowel) blockage or
  • Peritonitis (swelling of the lining of the abdomen or stomach) or
  • Urinary tract blockage—Should not be used in patients with these conditions.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins, under your skin, or into your muscle.

Precautions While Using This Medicine:

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred or loss of vision
chest pain, discomfort, or tightness
confusion
difficult or labored breathing
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
fast, slow, pounding, or irregular heartbeat or pulse
lightheadedness, dizziness, or fainting
sweating
twitches of the muscle visible under the skin
unusual tiredness or weakness
Incidence not known
Changes in patterns and rhythms of speech
cough
difficulty in moving
difficulty swallowing
disturbed color perception
double vision
halos around lights
hives
irregular, fast or slow, or shallow breathing
itching
loss of consciousness
muscle cramps and spasms
muscle pain or stiffness
night blindness
no blood pressure or pulse
noisy breathing
overbright appearance of lights
pain in the joints
pale or blue lips, fingernails, or skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
seizures
skin rash
slurred speech
stopping of the heart
trouble in speaking
tunnel vision
unconsciousness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose
Constipation
decreased sexual ability
difficult urination
dry mouth
enlarged pupils
muscle weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at site
drowsiness
headache
increased watering of the mouth
nausea
sleeplessness
sore throat
trouble sleeping
unable to sleep
vomiting
Incidence not known
Bloated
constricted, pinpoint, or small pupils (black part of eye)
diarrhea
dry mouth
excess air or gas in the stomach or intestines
feeling of warmth
full feeling
increase in mucous from the lungs
increased need to urinate
increased sweating
passing gas
passing urine more often
redness of the face, neck, arms and occasionally, upper chest
redness of the skin
skin rash
stomach cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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