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Ethacrynate sodium (Intravenous route)

Pronunciation:

eth-a-KRIN-ate SOE-dee-um

Brand Names:

  • Edecrin Sodium

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Cardiovascular Agent

Pharmacologic—

Ethacrynic Acid

Uses of This Medicine:

Ethacrynate sodium injection belongs to a group of medicines called loop diuretics or "water pills." Ethacrynate sodium is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine .

This medicine is available only with your doctor's prescription .

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of ethacrynate sodium injection in the pediatric population. Safety and efficacy have not been established .

Older adults—

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ethacrynate sodium injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dosage in patients receiving ethacrynate sodium injection .

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amikacin
  • Arsenic Trioxide
  • Bepridil
  • Digitoxin
  • Dofetilide
  • Droperidol
  • Furosemide
  • Gentamicin
  • Kanamycin
  • Ketanserin
  • Levomethadyl
  • Lithium
  • Metolazone
  • Neomycin
  • Netilmicin
  • Sotalol
  • Streptomycin
  • Tobramycin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alacepril
  • Amtolmetin Guacil
  • Aspirin
  • Benazepril
  • Bromfenac
  • Bufexamac
  • Captopril
  • Celecoxib
  • Choline Salicylate
  • Cilazapril
  • Clonixin
  • Cortisone
  • Delapril
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Enalaprilat
  • Enalapril Maleate
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fosinopril
  • Germanium
  • Ginseng
  • Gossypol
  • Ibuprofen
  • Ibuprofen Lysine
  • Imidapril
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lisinopril
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Moexipril
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Pentopril
  • Perindopril
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinapril
  • Ramipril
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Spirapril
  • Sulindac
  • Temocapril
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Trandolapril
  • Valdecoxib
  • Zofenopril

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anuria (not able to form urine) or
  • Electrolyte imbalance (low or high amounts of minerals in the blood), severe or
  • Watery diarrhea, severe—Should not use in patients with these conditions .
  • Diabetes—This medicine may increase the amount of sugar in the blood .
  • Hearing problems or
  • Hypochloremia (low chloride in the blood) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hyponatremia (low sodium in the blood) or
  • Hypovolemia (low blood volume) or
  • Liver disease (cirrhosis), advanced—Use with caution. This medicine may make these conditions worse .
  • Hypoproteinemia (low protein in the blood)—May decrease the effect of the medicine in the body .
  • Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins .

Precautions While Using This Medicine:

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor .

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare
Bleeding gums
bloating
clay-colored stools
constipation
darkened urine
indigestion
itching
large, flat, blue or purplish patches in the skin
loss of appetite
nausea
painful knees and ankles
pains in stomach, side, or abdomen, possibly radiating to the back
pinpoint red spots on skin
raised red swellings on the skin, the buttocks, legs, or ankles
skin rash
unpleasant breath odor
vomiting of blood
yellow eyes or skin
Incidence not determined
Anxiety
black, tarry stools
blood in urine
blurred vision
cold sweats
coma
confusion
convulsions (seizures)
cool, pale skin
cough or hoarseness
depression
dizziness
dry mouth
fast heartbeat
fever with or without chills
flushed, dry skin
fruit-like breath odor
general feeling of tiredness or weakness
headache
increased hunger
increased thirst
increased urination
joint pain, stiffness, or swelling
lower back, side, or stomach pain
nausea
nervousness
nightmares
painful or difficult urination
pale skin
shakiness
shortness of breath
slurred speech
sore throat
sores, ulcers, or white spots on the lips or in the mouth
sweating
swelling of the feet or lower legs
troubled breathing
unexplained weight loss
unusual bleeding or bruising
unusual tiredness or weakness
vomiting
watery and severe diarrhea

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
Confusion
decreased urination
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
increase in heart rate
irregular heartbeat
muscle cramps or pain
numbness, tingling, pain, or weakness in the hands or feet
rapid breathing
sunken eyes
thirst
trembling
weakness and heaviness of the legs
wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not determined
Continuing ringing or buzzing or other unexplained noise in ears
difficulty swallowing
fear
feeling of constant movement of self or surroundings
feeling of fullness in the ears
general feeling of discomfort or illness
hearing loss
irritation, or pain at injection site
mild diarrhea
sensation of spinning
stomach soreness or discomfort
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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