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Propranolol (Intravenous route)

Pronunciation:

proe-PRAN-oh-lol

Brand Names:

  • Inderal

Dosage Forms:

  • Solution

Classifications:

Therapeutic—

Cardiovascular Agent

Pharmacologic—

Beta-Adrenergic Blocker, Nonselective

Uses of This Medicine:

Propranolol injection is used to control fast heartbeats and abnormal heart rhythms .

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and at a regular rhythm .

This medicine is available only with your doctor's prescription .

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of propranolol injection in the pediatric population. Safety and efficacy have not been established .

Older adults—

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of propranolol injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment of dosage in patients receiving propranolol injection .

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Albuterol
  • Amiodarone
  • Arformoterol
  • Bambuterol
  • Bupivacaine
  • Bupivacaine Liposome
  • Bupropion
  • Clenbuterol
  • Clonidine
  • Clozapine
  • Colterol
  • Crizotinib
  • Diatrizoate
  • Diltiazem
  • Dronedarone
  • Epinephrine
  • Eslicarbazepine Acetate
  • Fenoldopam
  • Fenoterol
  • Fingolimod
  • Fluoxetine
  • Formoterol
  • Haloperidol
  • Hexoprenaline
  • Indacaterol
  • Isoetharine
  • Levalbuterol
  • Lidocaine
  • Lomitapide
  • Mefloquine
  • Mepivacaine
  • Metaproterenol
  • Nilotinib
  • Pirbuterol
  • Pixantrone
  • Prilocaine
  • Procaterol
  • Reproterol
  • Ritodrine
  • Salmeterol
  • Simeprevir
  • Terbutaline
  • Tocophersolan
  • Tretoquinol
  • Tulobuterol
  • Verapamil
  • Vilanterol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetohexamide
  • Acetyldigoxin
  • Alfuzosin
  • Amlodipine
  • Amtolmetin Guacil
  • Arbutamine
  • Aspirin
  • Benfluorex
  • Bromfenac
  • Bufexamac
  • Bunazosin
  • Celecoxib
  • Chlorpromazine
  • Chlorpropamide
  • Cholestyramine
  • Choline Salicylate
  • Cimetidine
  • Clonixin
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitoxin
  • Digoxin
  • Dihydroergotamine
  • Dipyrone
  • Disopyramide
  • Doxazosin
  • Ergotamine
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Felodipine
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fluvoxamine
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Guggul
  • Ibuprofen
  • Ibuprofen Lysine
  • Indomethacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Ketoprofen
  • Ketorolac
  • Lacidipine
  • Lercanidipine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Manidipine
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Metildigoxin
  • Mibefradil
  • Miglitol
  • Morniflumate
  • Moxisylyte
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nicardipine
  • Nifedipine
  • Niflumic Acid
  • Nilvadipine
  • Nimesulide
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenoxybenzamine
  • Phentolamine
  • Phenylbutazone
  • Phenylephrine
  • Piketoprofen
  • Piperine
  • Piroxicam
  • Pranidipine
  • Pranoprofen
  • Prazosin
  • Proglumetacin
  • Propoxyphene
  • Propyphenazone
  • Proquazone
  • Quinidine
  • Repaglinide
  • Rifapentine
  • Rizatriptan
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sertraline
  • Sodium Salicylate
  • St John's Wort
  • Sulindac
  • Tamsulosin
  • Tenoxicam
  • Terazosin
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Trimazosin
  • Troglitazone
  • Tubocurarine
  • Urapidil
  • Valdecoxib
  • Zileuton

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tobacco

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain)—May provoke chest pain if stopped too quickly .
  • Asthma or
  • Bradycardia (slow heartbeat) or
  • Heart block or
  • Heart failure—Should not use in patients with these conditions .
  • Diabetes or
  • Hyperthyroidism (overactive thyroid) or
  • Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .
  • Lung disease (e.g., bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .
  • Wolff-Parkinson-White syndrome (rare heart condition)—May cause a very slow heartbeat in patients with this condition .

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins .

Precautions While Using This Medicine:

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor .

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred vision
chest pain or discomfort
confusion
decreased urine output
dilated neck veins
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
extreme fatigue
irregular breathing
lightheadedness, dizziness, or fainting
shortness of breath
slow or irregular heartbeat
sweating
swelling of face, fingers, feet, or lower legs
tightness in chest
troubled breathing
unusual tiredness or weakness
weight gain
wheezing
Rare
Blisters, hives, or itching
fever and chills
general feeling of discomfort or illness
hair loss
headaches
muscle or joint pain
skin rash
sore throat
swollen glands
Incidence not determined
Abdominal pain, usually after eating a meal
abdominal tenderness
black, tarry stools
blood in urine
bloody nose
bloody stools
body aches or pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
congestion
constipation
cough
decreased awareness or responsiveness
diarrhea
difficult or labored breathing
dryness or soreness of throat
general feeling of tiredness or weakness
heavier menstrual periods
hoarseness
lower back or side pain
mimicry of speech or movements
mutism
nausea
negativism
no blood pressure or pulse
noisy breathing
painful or difficult urination
paleness or cold feeling in fingertips and toes
peculiar postures or movements, mannerisms, or grimacing
pinpoint red or purple spots on skin
rectal bleeding
reddened skin
runny nose
severe sleepiness
sores on the skin
sores, ulcers, or white spots on lips or in mouth
stopping of heart
tender, swollen glands in neck
tingling or pain in fingers or toes when exposed to cold
trouble in swallowing
unconsciousness
unusual bleeding or bruising
voice changes
vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare
Decreased interest in sexual intercourse
dry eyes
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
pain of penis on erection
skin irritation or rash, including rash that looks like psoriasis
thinning of hair
Incidence not determined
Confusion about identity, place, and time
crying
depersonalization
disturbed color perception
double vision
dysphoria
euphoria
halos around lights
loss of strength or energy
loss of vision
mental depression
muscle weakness
night blindness
overbright appearance of lights
paranoia
quick to react or overreact emotionally
rapidly changing moods
seeing, hearing, or feeling things that are not there
short-term memory loss
sleeplessness
trouble sleeping
tunnel vision
unable to sleep
unusual drowsiness, dullness, or feeling of sluggishness
vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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