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Esmolol (Intravenous route)

Pronunciation:

ES-moe-lol

Brand Names:

  • Brevibloc
  • Esmolol HCl

Dosage Forms:

  • Solution

Classifications:

Therapeutic—

Cardiovascular Agent

Pharmacologic—

Beta-Adrenergic Blocker, Cardioselective

Uses of This Medicine:

Esmolol is used to control rapid heartbeats or abnormal heart rhythms. This medicine is also used to treat fast heartbeat and high blood pressure during surgery, after surgery, or during other medical procedures .

This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .

This medicine is available only with your doctor's prescription .

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of esmolol in the pediatric population. Safety and efficacy have not been established .

Older adults—

No information is available on the relationship of age to the effects of esmolol in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving esmolol .

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Albuterol
  • Amiodarone
  • Arformoterol
  • Bambuterol
  • Clenbuterol
  • Clonidine
  • Colterol
  • Crizotinib
  • Diltiazem
  • Dronedarone
  • Fenoldopam
  • Fenoterol
  • Fingolimod
  • Formoterol
  • Hexoprenaline
  • Indacaterol
  • Isoetharine
  • Lacosamide
  • Levalbuterol
  • Metaproterenol
  • Olodaterol
  • Pirbuterol
  • Procaterol
  • Reproterol
  • Ritodrine
  • Salmeterol
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Verapamil
  • Vilanterol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetohexamide
  • Acetyldigoxin
  • Alfuzosin
  • Amlodipine
  • Amtolmetin Guacil
  • Arbutamine
  • Aspirin
  • Benfluorex
  • Bromfenac
  • Bufexamac
  • Bunazosin
  • Celecoxib
  • Chlorpropamide
  • Choline Salicylate
  • Clonixin
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitoxin
  • Digoxin
  • Dipyrone
  • Doxazosin
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Felodipine
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Ibuprofen
  • Ibuprofen Lysine
  • Indomethacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Ketoprofen
  • Ketorolac
  • Lacidipine
  • Lercanidipine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Manidipine
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Metildigoxin
  • Mibefradil
  • Miglitol
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Moxisylyte
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nicardipine
  • Nifedipine
  • Niflumic Acid
  • Nilvadipine
  • Nimesulide
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenoxybenzamine
  • Phentolamine
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranidipine
  • Pranoprofen
  • Prazosin
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Repaglinide
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • St John's Wort
  • Sulindac
  • Tamsulosin
  • Tenoxicam
  • Terazosin
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Trimazosin
  • Troglitazone
  • Urapidil
  • Valdecoxib

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bradycardia (slow heartbeat) or
  • Heart block or
  • Heart failure—Should not use in patients with these conditions .
  • Diabetes or
  • Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat .
  • Hypotension (low blood pressure)—May worsen this condition .
  • Kidney disease—Use with caution. The effects may be increased because of slower removal from the body .
  • Lung disease (e.g. asthma, bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition .

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins .

Precautions While Using This Medicine:

Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to another medicine that works the same way. If you have any concerns about this, talk to your doctor .

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
increased sweating
unusual tiredness or weakness
Less common
Itching of skin
numbness and tingling of face, fingers, or toes
pain in arms, legs, or lower back, especially pain in calves and/or heels upon exertion
pale, bluish-colored, or cold hands or feet
weak or absent pulses in legs
Rare
Blue lips and fingernails
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
changes in skin color
changes in vision
chest pain or discomfort
convulsions
coughing that sometimes produces a pink frothy sputum
decrease in frequency of urination
decrease in urine volume
delusions
dementia
difficult, fast, noisy breathing, sometimes with wheezing
difficulty in passing urine (dribbling)
difficulty with speaking
feeling of warmth
feeling unusually cold
lightheadedness, dizziness, or fainting
loss of bladder control
muscle spasm or jerking of all extremities
no heartbeat
pain, tenderness, or swelling of foot or leg
painful urination
paleness of skin
peeling of skin
redness of the face, neck, arms and occasionally, upper chest
shivering
shortness of breath
slow or irregular heartbeat
small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope
sudden loss of consciousness
swelling, redness, or burning of skin where the needle is placed
tightness in chest

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
Dilated neck veins
extreme fatigue
irregular breathing
no blood pressure or pulse
stopping of heart
swelling of face, fingers, feet, or lower legs
unconsciousness
weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Hardening or thickening of skin where the needle is placed
nausea
Less common
Anxiety
dry mouth
headache
hyperventilation
irritability
nervousness
restlessness
shaking
sleepiness or unusual drowsiness
trouble sleeping
vomiting
Rare
Acid or sour stomach
belching
change in taste or bad, unusual, or unpleasant (after) taste
difficulty having a bowel movement (stool)
discouragement
feeling sad or empty
heartburn
indigestion
lack of appetite
lack or loss of strength
loss of interest or pleasure
shoulder pain
stomach soreness, discomfort, upset, or pain
stuffy nose
tiredness
trouble concentrating
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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