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Dinoprost tromethamine (Injection route)

Dosage Forms:

  • Injectable
  • Solution

Classifications:

Pharmacologic—

Dinoprost

Uses of This Medicine:

Dinoprost is used to cause abortion during the second trimester of pregnancy. It may also be used for other purposes as determined by your doctor.

Dinoprost is to be administered only by or under the immediate care of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not specifically included in product labeling, dinoprost is used in certain patients for the following medical procedures:

  • Angiography (x-ray pictures of the blood vessels)
  • Inducing labor

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia (history of)—In some patients, abortion with dinoprost may result in loss of blood that may require a transfusion
  • Asthma (or history of) or
  • Lung disease—Dinoprost may cause narrowing of the blood vessels in the lungs or narrowing of the lung passages
  • Type 2 diabetes mellitus (history of)
  • Epilepsy (or history of)—Rarely, dinoprost has been reported to cause seizures in patients who have epilepsy
  • Fibroid tumors of the uterus or
  • Uterus surgery (history of)—There is an increased risk of rupture of the uterus
  • Glaucoma—Rarely the pressure within the eye has increased and constriction of the pupils has occurred during the use of dinoprost
  • Heart or blood vessel disease (or history of) or
  • High blood pressure (history of) or
  • Low blood pressure (history of)—Dinoprost may cause changes in heart function or blood pressure changes
  • Jaundice (history of)
  • Kidney disease (or history of)
  • Liver disease (or history of)—The body may not get dinoprost out of the bloodstream at the usual rate, which may make the medicine work longer or cause toxic effects

Proper Use of This Medicine:

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For aborting a pregnancy:
      • Adults—Your doctor will slowly inject 40 milligrams (mg) into the amniotic sac (bag that surrounds the fetus). If needed, your doctor may give you another dose in twenty–four hours to complete the abortion.
    • For inducing labor:
      • Adults—Your doctor will slowly inject 1 to 4 mg a day into a vein.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare
Chest pain
coughing (sudden)
cramping of the uterus (continuing and severe)
fast heartbeat
hives
numbness in legs or other body parts
pale, cool, or blotchy skin on arms or legs
pressing or painful feeling in chest
redness and itching of skin
shortness of breath
slow or irregular heartbeat
swelling of eyelids, face, or inside of nose
tightness in chest
trouble in breathing
weak or absent pulse in arms or legs
wheezing

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare
Abdominal or stomach pain (severe or continuing)
blood in urine
constipation
decreased frequency of urination
difficult or painful urination
double vision or burning eyes
pain in legs, back, or shoulder
tender or mildly bloated abdomen

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Diarrhea
nausea
stomach cramps or pain
vomiting
Less common
Anxiety
breast fullness or tenderness
burning feeling in breasts
chills or shivering
cough (continuing)
dizziness
drowsiness
fever (temporary)
flushing or redness of face
headache
hiccups
increased sweating
inflammation and pain at place of injection
unusual thirst

After the procedure has been completed, this procedure may still produce some side effects that need medical attention. Check with your doctor if you notice any of the following side effects:

Chills or shivering (continuing)
fever (continuing)
foul-smelling vaginal discharge
pain in lower abdomen
unusual increase in uterus bleeding

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 6/12/2013

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