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Triptorelin (Intramuscular route)

Pronunciation:

trip-toe-REL-in

Brand Names:

  • Trelstar
  • Trelstar Depot
  • Trelstar LA

Dosage Forms:

  • Powder for Suspension

Classifications:

Therapeutic—

Antineoplastic Agent

Pharmacologic—

Luteinizing Hormone Releasing Hormone Agonist

Uses of This Medicine:

Triptorelin is used to treat advanced prostate cancer in men. It is a hormone that is similar to the one normally released from the hypothalamus gland in the brain. When given on a regular basis to men, triptorelin decreases testosterone levels which helps treat prostate cancer.

This medicine is to be given only by or under the supervision of a doctor.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of triptorelin in the pediatric population. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of triptorelin in the elderly.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersXStudies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bladder blockage or
  • Diabetes or
  • Heart or blood vessel disease or
  • Hyperglycemia (high blood sugar) or
  • Spinal cord problems—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into your muscle (usually in the buttocks). This medicine needs to be given on a fixed schedule. Make sure you keep all of your appointments.

Precautions While Using This Medicine:

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive the medicine.

When you first start using this medicine, some of your symptoms might get worse or you might have new symptoms for a short time. Tell your doctor right away if you have bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating.

This medicine may cause changes in your blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.

This medicine may increase your risk of having a heart attack or stroke. Call your doctor right away if you have chest pain or discomfort; pain or discomfort in the arms, jaw, back, or neck; shortness of breath; nausea; sweating; or vomiting.

Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common
Bladder pain
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody or cloudy urine
blurred vision
burning while urinating
chest pain
cough producing mucus
decrease in urine volume or frequency of urination
difficult or labored breathing
difficult, burning, or painful urination
difficulty in passing urine
dizziness
dry mouth
flushed, dry skin
frequent urge to urinate
fruit-like breath odor
headache
high blood pressure
increased hunger
increased thirst
increased urination
loss of consciousness
lower back or side pain
nausea
nervousness
pale skin
pounding in the ears
rapid weight gain
shortness of breath
slow or fast heartbeat
stomachache
sweating
tightness in the chest
tingling of the hands or feet
troubled breathing
troubled breathing with exertion
unexplained weight loss
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
vomiting
wheezing
Incidence not known
Anxiety
changes in skin color
changes in vision
chest discomfort
cold, clammy, or pale skin
confusion
dizziness or lightheadedness
fainting
inability to speak
irregular heartbeats
numbness or tingling in the face, arms, or legs
pain
pain or discomfort in the arms, jaw, back, or neck
pain, redness, or swelling in the arm or leg
seizures
severe or sudden headache
slow heart rate
slurred speech
sudden shortness of breath or troubled breathing
temporary blindness
tenderness
trouble speaking, thinking, or walking
weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bone pain
chills
decrease in testicle size
diarrhea
fever
decreased interest in sexual intercourse
feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
general feeling of discomfort or illness
inability to have or keep an erection
joint pain
leg pain
loss in sexual ability, desire, drive, or performance
loss of appetite
muscle aches and pains
redness of the face, neck, arms, and occasionally, upper chest
runny nose
shivering
sore throat
sudden sweating
trouble sleeping
Less common
Acid or sour stomach
back pain
belching
body aches or pain
breast pain
burning, dry, or itching eyes
congestion
crying
depersonalization
difficulty having a bowel movement (stool)
difficulty with moving
discharge or excessive tearing
dysphoria
euphoria
eye pain
heartburn
hoarseness
indigestion
injection site pain
itching
lack or loss of strength
leg cramps
loss of appetite
mental depression
muscle aching or cramping
muscle pains or stiffness
pain
paranoia
quick to react or overreact emotionally
rapidly changing moods
rash
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
runny nose
sleeplessness
stomach discomfort, upset, or pain
swelling of the breasts or breast soreness in both females and males
swollen joints
tender, swollen glands in the neck
trouble with swallowing
voice changes
weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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