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Minocycline (Subgingival route)

Pronunciation:

min-oh-SYE-kleen

Classifications:

Chemical—

Tetracycline (class)

Uses of This Medicine:

Minocycline is used to help treat periodontal disease (a disease of your gums). Periodontal disease is caused by bacteria growing beneath the gum line. Minocycline works by keeping the number of bacteria from growing. Lowering the amount of bacteria helps to reduce inflammation and swelling in your mouth, and the amount of bleeding around the teeth. Minocycline is placed in deep gum pockets next to your teeth in order to reduce the depth of the pockets.

This medicine will be applied by your dentist or other oral health care professional.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Use is not recommended in infants and children up to 8 years of age. Tetracyclines, such as minocycline, may cause permanent discoloration of teeth and slow down the growth of bones. The safety and effectiveness of minocycline have not been determined in children 8 years of age or older.

Older adults—

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of minocycline in the elderly with use in other age groups.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast-feeding—

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acitretin

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amoxicillin
  • Ampicillin
  • Atazanavir
  • Bacampicillin
  • Cloxacillin
  • Dicloxacillin
  • Digoxin
  • Isotretinoin
  • Methicillin
  • Nafcillin
  • Oxacillin
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Procaine
  • Penicillin V
  • Piperacillin
  • Pivampicillin
  • Sultamicillin
  • Temocillin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Iron
  • Vitamin A

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of This Medicine:

The amount of medicine that is put into your gum pockets will be determined by your dentist. The number of teeth that need treatment and the depth of the pockets will determine the amount of medicine that is used.

After the medicine is placed in your mouth, try to avoid any actions that may cause the medicine to come out. For example:

  • Do not chew hard, crunchy, or sticky foods for 1 week after treatment.
  • Do not brush near any treated areas. Wait 12 hours after the procedure before brushing the other teeth.
  • Do not use dental floss or any other cleaning tools that go between the teeth for 10 days after treatment.
  • Do not probe or pick at the treated areas with your tongue, toothpicks, or fingers.

Precautions While Using This Medicine:

Check with your dentist as soon as possible if you have pain or swelling or other problems in the treated areas.

It is very important that your dentist check your progress. Do not miss any dental appointments.

Tetracyclines, such as minocycline, may cause your skin to be more sensitive to sunlight than normal. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. After receiving minocycline:

  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Wear protective clothing, including a hat. Also, wear sunglasses.
  • Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
  • Apply a sun block lip balm or lipstick that has an SPF of at least 15 to protect your lips.
  • Do not use a sunlamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your dentist or doctor.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Bleeding from the gums
chills
dental pain
fever
pain, redness, and swelling in the mouth
problems with teeth
redness or swelling of the gums
toothache
Less common
Bad taste in the mouth
discharge from the gums
foul breath odor
painful sores in the mouth
problems in the lining of the mouth

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Headache
Less common
Acid or sour stomach
belching
cough
heartburn
increased sensitivity to sunlight
indigestion
pain
pain in the joints or muscles
runny nose
sneezing
sore throat
stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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