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Micafungin (Intravenous route)

Pronunciation:

mye-ka-FUN-jin

Brand Names:

  • Mycamine

Dosage Forms:

  • Powder for Solution

Classifications:

Therapeutic—

Antifungal

Pharmacologic—

Glucan Synthesis Inhibitor

Chemical—

Echinocandin

Uses of This Medicine:

Micafungin injection is used to help the body overcome serious fungus infections, such as candidemia, acute disseminated candidiasis, candida peritonitis and abscess, and esophageal candidiasis. Micafungin is also used to prevent candida infections in patients having a stem cell transplant. .

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of micafungin injection in children younger than 4 months of age. Safety and efficacy have not been established.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of micafungin injection in the elderly.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Itraconazole
  • Nifedipine
  • Sirolimus

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems (eg, hemolysis or hemolytic anemia) or
  • Kidney problems—Use with caution. May make these conditions worse.
  • Liver disease, moderate to severe—Higher blood levels of micafungin may result, increasing the chance of side effects.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. This medicine is given slowly, so the needle will have to remain in place for at least 1 hour.

Precautions While Using This Medicine:

It is very important that your doctor check your progress closely to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor or nurse right away if you have a rash, itching, swelling of the face, tongue, and throat, trouble breathing, or chest pain after you get the injection. .

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Black, tarry, stools
cough
decreased frequency or amount of urine
fast, pounding, or irregular heartbeat or pulse
fever or chills
increased thirst
loss of appetite
lower back or side pain
nausea or vomiting
painful or difficult urination
pale skin
pinpoint red spots on the skin
shortness of breath
swelling of the face, fingers, or lower legs
trouble breathing
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
weight gain
Less common
Bone pain
changes in skin color, pain, tenderness, or swelling of the foot or leg
chest pain
convulsions
drowsiness
mood or mental changes
muscle pain or cramps
muscle spasms or twitching
numbness or tingling in the hands, feet, or lips
seizures
swollen glands
trembling
Rare
Abdominal or stomach cramps
blurred vision
dizziness
headache
nervousness
pounding in the ears
slow or fast heartbeat
weakness or heaviness of the legs
Incidence not known
Agitation
back, leg, or stomach pain
blistering, peeling, or loosening of the skin
bruising
diarrhea
fast, weak pulse
general body swelling
hives
hostility or irritability
itching
joint pain
lightheadedness
light-colored stools
nosebleeds
persistent bleeding or oozing from puncture sites, mouth, or nose
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
skin rash or redness
vomiting of blood
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Cold sweats
cool, pale skin
depression
flushing
increased hunger
nightmares
slurred speech
welts
Less common
Bluish color
feeling unusually cold or shivering
Rare
Belching
change in taste
confusion as to time, place, or person
difficulty having a bowel movement (stool)
hallucinations
heartburn
hiccups
injection site pain
sleepiness or unusual drowsiness
stomach discomfort or upset
unusual excitement, nervousness, or restlessness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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