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Droperidol (Injection route)

Pronunciation:

droe-PER-i-dol

Brand Names:

  • Inapsine

Dosage Forms:

  • Injectable
  • Solution

Warnings:

Injection route(Solution)

Cases of QT prolongation and/or torsade de pointes, some fatal, have been reported in patients receiving droperidol at doses at or below recommended doses. All patients should undergo a 12-lead ECG prior to administration of droperidol to determine if a prolonged QT interval (i.e., QTc greater than 440 msec for males or 450 msec for females) is present. Do not administer droperidol if there is a prolonged QT interval. Droperidol is contraindicated in patients with known or suspected QT prolongation, including patients with congenital long QT syndrome. Administer droperidol with extreme caution to patients who may be at risk for development of prolonged QT syndrome, are over 65 years old, abuse alcohol, or when used concomitantly with benzodiazepines, volatile anesthetics, and IV opiates. ECG monitoring should be performed prior to treatment and continued for 2 to 3 hours after completing treatment to monitor for arrhythmias .

Classifications:

Therapeutic—

Antiemetic

Pharmacologic—

Dopamine Antagonist

Chemical—

Butyrophenone

Uses of This Medicine:

Droperidol injection is used to prevent the nausea and vomiting that may occur after surgery or diagnostic procedures.

This medicine is to be given only by or under the direct supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, droperidol may be used for:

  • Preventing nausea and vomiting caused by chemotherapy (cancer medicines).
  • Severe agitation related to mental disorders.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Appropriate studies have not been performed on the relationship of age to the effects of droperidol injection in children younger than 2 years of age. Safety and efficacy have not been established.

Older adults—

No information is available on the relationship of age to the effects of droperidol injection in geriatric patients. However, elderly patients are more likely to have age-related heart or kidney problems, which may require caution and an adjustment in the dose for patients receiving droperidol injection.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acetophenazine
  • Amifampridine
  • Bepridil
  • Bromperidol
  • Cisapride
  • Clozapine
  • Dronedarone
  • Levomethadyl
  • Mesoridazine
  • Molindone
  • Perphenazine
  • Pimozide
  • Pipamperone
  • Piperaquine
  • Remoxipride
  • Sparfloxacin
  • Thioridazine
  • Tiapride
  • Triflupromazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Acetazolamide
  • Acrivastine
  • Ajmaline
  • Alfuzosin
  • Amiloride
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amlodipine
  • Amoxapine
  • Apomorphine
  • Aprindine
  • Aranidipine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Azosemide
  • Bedaquiline
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Bretylium
  • Brofaromine
  • Bumetanide
  • Bupropion
  • Buserelin
  • Canrenoate
  • Castor Oil
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Chlorthalidone
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clopamide
  • Clorgyline
  • Crizotinib
  • Cyclobenzaprine
  • Cyclothiazide
  • Dabrafenib
  • Dasatinib
  • Delamanid
  • Desipramine
  • Deslorelin
  • Dibenzepin
  • Diltiazem
  • Disopyramide
  • Docusate
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Ebastine
  • Encainide
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Ethacrynic Acid
  • Etozolin
  • Felodipine
  • Fendiline
  • Fenquizone
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Flunarizine
  • Fluoxetine
  • Fluspirilene
  • Fluvoxamine
  • Formoterol
  • Foscarnet
  • Furazolidone
  • Furosemide
  • Gallopamil
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indapamide
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ketoconazole
  • Lacidipine
  • Lactulose
  • Lapatinib
  • Lazabemide
  • Leuprolide
  • Levofloxacin
  • Lidoflazine
  • Linezolid
  • Lithium
  • Lopinavir
  • Lorcainide
  • Lumefantrine
  • Mannitol
  • Mefloquine
  • Methadone
  • Metolazone
  • Metronidazole
  • Mianserin
  • Mibefradil
  • Mifepristone
  • Moclobemide
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nafarelin
  • Nefazodone
  • Nialamide
  • Nicardipine
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pargyline
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Phenelzine
  • Piretanide
  • Pirmenol
  • Polythiazide
  • Posaconazole
  • Prajmaline
  • Probucol
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinethazone
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Risperidone
  • Ritanserin
  • Salmeterol
  • Saquinavir
  • Selegiline
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sorbitol
  • Sotalol
  • Spiramycin
  • Spironolactone
  • Sulfamethoxazole
  • Sultopride
  • Sunitinib
  • Suvorexant
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Ticrynafen
  • Tizanidine
  • Toloxatone
  • Toremifene
  • Torsemide
  • Tranylcypromine
  • Trazodone
  • Triamterene
  • Trichlormethiazide
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Urea
  • Vandetanib
  • Vasopressin
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Xipamide
  • Zimeldine
  • Zolmitriptan
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Levodopa

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bradycardia (slow heartbeat) or
  • Cardiac hypertrophy (heart is larger than normal) or
  • Congestive heart failure or
  • Heart disease or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Pheochromocytoma (adrenal gland tumor)—May cause side effects to become worse.
  • Cardiac arrhythmias (abnormal heart beats) or
  • Hypotension (low blood pressure)—Use with caution. May make these conditions worse.
  • Congenital long QT syndrome (heart rhythm problem) or
  • QT prolongation (heart rhythm problem)—Should not be used in patients with these conditions.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or a vein.

Precautions While Using This Medicine:

Your doctor will check your progress after you receive this medicine. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

Tell your doctor right away if you have any change in your heart rhythm. The symptoms may include feeling dizzy or faint, or having a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Check with your doctor right away if you have difficulty breathing, a fast heartbeat, a high fever, a change in blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

Droperidol will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or other seizure medicines; and muscle relaxants. Check with your doctor before taking any of these medicines after you receive droperidol.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Blurred vision
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
sweating
unusual tiredness or weakness
Less common
Chills
cough
difficulty with breathing
difficulty with swallowing
dizziness
fast heartbeat
noisy breathing
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
skin rash, hives, or itching
tightness in the chest
Incidence not known
Chest pain or discomfort
fainting
fast, pounding, or irregular heartbeat or pulse
irregular or slow heart rate
low blood pressure or pulse
severe confusion or loss of consciousness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Anxiety
drowsiness
restlessness
trouble sitting still
Incidence not known
Difficulty with speaking
drooling
loss of balance control
muscle trembling, jerking, or stiffness
seeing, hearing, or feeling things that are not there
shuffling walk
stiffness of the limbs
twisting movements of the body
uncontrolled movements, especially of the face, neck, and back

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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