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Dipyridamole (Oral route, intravenous route)

Pronunciation:

dye-pir-ID-a-mole

Brand Names:

  • Persantine

Dosage Forms:

  • Tablet
  • Capsule, Extended Release
  • Solution
  • Tablet, Extended Release

Classifications:

Therapeutic—

Platelet Aggregation Inhibitor

Pharmacologic—

Phosphodiesterase Inhibitor

Uses of This Medicine:

Dipyridamole is used to lessen the chance of stroke or other serious medical problems that may occur when a blood vessel is blocked by blood clots. It is given only when there is a larger-than-usual chance that these problems may occur. For example, it is given to people who have had diseased heart valves replaced by mechanical valves, because dangerous blood clots are especially likely to occur in these patients. Dipyridamole works by helping to prevent dangerous blood clots from forming.

Dipyridamole may also be used for other heart and blood conditions as determined by your doctor.

Dipyridamole is also sometimes used as part of a medical test that shows how well blood is flowing to your heart. For information on this use of dipyridamole, see Dipyridamole—Diagnostic (Systemic).

Dipyridamole is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

This medicine has been tested only in adults and in children older than 12 years of age. There is no specific information comparing use of dipyridamole in children younger than 12 years of age with use in other age groups.

Older adults—

Dipyridamole has not been studied specifically in older people taking the medicine regularly to prevent blood clots from forming. Although there is no specific information comparing this use of dipyridamole in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Riociguat

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amtolmetin Guacil
  • Anagrelide
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Bivalirudin
  • Bromfenac
  • Bufexamac
  • Celecoxib
  • Certoparin
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clonixin
  • Clopidogrel Hydrogen Sulfate
  • Dabigatran Etexilate
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Duloxetine
  • Enoxaparin
  • Eptifibatide
  • Escitalopram
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Heparin Sodium
  • Ibuprofen
  • Ibuprofen Lysine
  • Ketoprofen
  • Ketorolac
  • Lepirudin
  • Levomilnacipran
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Milnacipran
  • Morniflumate
  • Nabumetone
  • Nadroparin
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Pranoprofen
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C, Human
  • Reviparin
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sertraline
  • Sodium Salicylate
  • Streptokinase
  • Sulfinpyrazone
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolfenamic Acid
  • Tolmetin
  • Treprostinil
  • Valdecoxib
  • Venlafaxine
  • Vortioxetine
  • Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenosine
  • Indomethacin
  • Tenecteplase

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Chest pain—The chance of side effects may be increased
  • Low blood pressure—Large amounts of dipyridamole can make your condition worse

Proper Use of This Medicine:

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, dipyridamole must be taken in regularly spaced doses, as ordered by your doctor.

This medicine works best when taken with a full glass (8 ounces) of water at least 1 hour before or 2 hours after meals. However, to lessen stomach upset, your doctor may want you to take the medicine with food or milk.

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For preventing blood clots:
    • For oral dosage form (tablets):
      • Adults—The usual dose is 75 to 100 milligrams (mg) four times a day taken together with an anticoagulant (blood-thinning) medicine.
      • Children—Use and dose must be determined by your doctor.

Missed dose—

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using This Medicine:

Dipyridamole is sometimes used together with an anticoagulant (blood thinner) or aspirin. The combination of medicines may provide better protection against the formation of blood clots than any of the medicines used alone. However, the risk of bleeding may also be increased when dipyridamole is taken with aspirin. To reduce the risk of bleeding:

  • Do not take aspirin, or any combination medicine containing aspirin, unless the same doctor who directed you to take dipyridamole also directs you to take aspirin. This is especially important if you are taking an anticoagulant together with dipyridamole.
  • If you have been directed to take aspirin together with dipyridamole, take only the amount of aspirin ordered by your doctor . If you need a medicine to relieve pain or a fever, your doctor may not want you to take extra aspirin. It is a good idea to discuss this with your doctor, so that you will know ahead of time what medicine to take.
  • Your doctor should check your progress at regular visits.

Tell all medical doctors and dentists you go to that you are taking dipyridamole, and whether or not you are taking an anticoagulant (blood thinner) or aspirin together with it.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare
Chest pain
gallstones
tightness or swelling of neck
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Abdominal or stomach cramps
diarrhea
dizziness or lightheadedness
Less common
Flushing
headache
nausea or vomiting
weakness
Rare
General discomfort and/or unusual tiredness or weakness
hair loss
joint pain or swelling
muscle pain
runny nose
sneezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 11/4/2014

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