Skip to main content

Cevimeline (Oral route)

Pronunciation:

se-VI-me-leen

Brand Names:

  • Evoxac

Dosage Forms:

  • Capsule

Classifications:

Therapeutic—

Central Nervous System Agent

Pharmacologic—

Cholinergic

Uses of This Medicine:

Cevimeline is used to treat the symptoms of dry mouth often experienced by patients with Sjogren's syndrome. It works by causing certain mouth glands to produce more saliva.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of cevimeline in children with use in other age groups.

Older adults—

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cevimeline in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast-feeding—

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma, uncontrolled, or
  • Cholelithiasis (gallstones), or
  • Heart disease, or
  • Nephrolithiasis (kidney stones), or
  • Eye conditions in which contraction of the pupils is undesirable (e.g., acute iritis and narrow-angle glaucoma), or
  • Pulmonary disease other than asthma

Proper Use of This Medicine:

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For the treatment of dry mouth in patients with Sjogren's syndrome:
      • Adults—30 milligrams three times a day
      • Children—Use and dose must be determined by your doctor.

Missed dose—

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using This Medicine:

If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for signs of your receiving too much medicine.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines, such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. This medicine may also cause a change in vision that could cause you to see less well at night. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are unable to see well, or if you are dizzy or are not alert.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
Difficulty breathing
fast heartbeat
itching
Rare
Chest pain
fainting or light-headedness when getting up from a lying or a sitting position
swelling of gums or tongue
Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

Blurring or loss of vision
chest pain
cold, clammy skin
diarrhea, continuous and severe
disturbed color vision
dizziness, faintness, or light-headedness when getting up from a lying or sitting position
difficult or labored breathing
fast, pounding, slow, or irregular heartbeat
fast, weak pulse
headache
mental confusion
nausea
pounding in ears
shaking or trembling of hands or feet
shortness of breath
stomach cramps or pain
sweating
tearing of the eyes

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
Bloody or cloudy urine
blurred vision
chest pain
cough
cracks in skin
difficult, burning , or painful urination
dizziness
dry or itching eyes
earache
feeling of constant movement of self or surroundings
itching of vagina, genital, or other skin area
lower back pain
redness or pain in eye
ringing or buzzing in the ears
scaling of skin
shortness of breath
skin rash
soreness or redness of skin
sores, ulcers, or white spots on tongue, lips, or inside of mouth
stiffness of muscles
swelling of hands, ankles, feet, or lower legs
swelling on side of face and jaw, with or without pain
tense muscles

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Excessive sweating
nausea
runny or stuffy nose
Less common
Abdominal pain
belching
bloating or swelling of face, hands, feet, or lower legs
bloody nose
bone or joint pain
burning, dry, or itching feeling in eye
change in vision
chills
constipation
cough, mucus-producing
decreased touch sensation
depression
diarrhea
dry mouth
eye pain
feelings of warmth in face, neck, arms, and occasionally, chest
fever
heartburn
hiccups
injury
itching
leg cramps
loss of appetite
migraine headache
mood or mental changes
muscle aches, pain, or stiffness
pain and swelling of eye, eyelid, or inner lining of eye
pain on side of face and jaw
pain, swelling, or redness of joints
postoperative pain
rapid weight gain
shortness of breath
skin disorder
tightness in chest
tooth disorders or pain
trembling or shaking of hands or feet
trouble in sleeping
unusual bleeding or bruising
unusual tiredness or weakness
vomiting
watering of mouth
weight loss
Rare
Abnormal crying
deep, dark, purple bruise
swelling or puffiness of face
temperature sensation changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

Copyright © 1984- Thomson Micromedex. All rights reserved.

Thomson & A.D.A.M