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Cefuroxime (Injection route, intravenous route)

Pronunciation:

sef-ue-ROX-eem

Brand Names:

  • Zinacef

Dosage Forms:

  • Powder for Solution
  • Solution

Classifications:

Therapeutic—

Antibiotic

Pharmacologic—

2nd Generation Cephalosporin

Uses of This Medicine:

Cefuroxime is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies—

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Children—

This medicine has been tested in children and, in effective doses, has not shown to cause different side effects or problems than it does in adults.

Older adults—

This medicine has been tested in the elderly and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy—

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast-feeding—

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Colitis, history of or
  • Gastrointestinal disease, history of— cefuroxime may make these worse
  • Kidney disease or
  • Liver disease or
  • Poor nutritional status—these may be worsened by cefuroxime and you may need to have vitamin K
  • Kidney problems, temporary or permanent— these may effect how much cefuroxime is in your body, reducing your dose might be needed.

Proper Use of This Medicine:

Dosing—

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form
      • Adults and teenagers—750 mg to 3 grams every six to eight hours usually for 5 to 14 days, injected into a muscle or vein. Gonorrhea is treated with a single dose of 1.5 grams, injected into a muscle; the total 1.5-gram dose is divided into two doses and injected into muscles at two separate places on the body, and given along with a single, oral 1-gram dose of probenecid.
      • Infants and children 1 month of age and older—12.5 to 150 mg per kg (5.68 to 68 mg per pound) of body weight every six to eight hours, injected into a muscle or vein.
      • Newborns—30 to 100 mg per kg (13.6 to 45.5 mg per pound) of body weight every eight to twelve hours, injected into a vein.

Missed dose—

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Consult your health care professional about how to store this medicine.

Precautions While Using This Medicine:

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
Black, tarry stools
chest pain
chills
cough
fever
painful or difficult urination
shortness of breath
sore throat
sores, ulcers, or white spots on lips or in mouth
swollen glands
unusual bleeding or bruising
unusual tiredness or weakness
Less common
Abdominal or stomach cramps
abdominal or stomach tenderness or pain
bloating
bluish color or changes in skin color
diarrhea, watery and severe, which may also be bloody
difficulty in breathing or swallowing, wheezing, shortness of breath
fast heartbeat
fever
hives or welts
increased thirst
muscle spasm or jerking of all extremities
nausea or vomiting
pain
skin itching, rash, or redness
sudden loss of consciousness
swelling of face, throat, or tongue
swelling of foot or leg
tenderness
unusual weight loss
Rare
Blistering, peeling, loosening of skin
bloody or cloudy urine
dizziness
fast heartbeat
greatly decreased frequency of urination or amount of urine
hearing loss, mild to moderate
joint or muscle pain
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
red or irritated eyes
redness, tenderness, itching, burning, or peeling of skin
red skin lesions, often with a purple center
sore throat
tightness in chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Gas
loss of appetite

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Last Updated: 4/4/2014

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