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Dmae

What is it?

DMAE is an abbreviation for Dimethylaminoethanol. It works by speeding up the production of acetylcholine, a chemical found in the brain. Acetylcholine carries messages between brain cells, and from the brain to the muscles that control body movements. DMAE is used to improve muscle reflexes and treat movement disorders such as tardive dyskinesia. DMAE has been used to treat children with hyperactivity disorders, decreased attention span and irritability. It has been used to treat dementia, memory problems and Alzheimer's disease. Recently, DMAE has been used for wrinkles, aging or liver spots and to extend a person's life span, but its use in these treatments may not be effective.

Other names for DMAE include: Deanol, Deanol acetamidobenzoate and Dimethylethanolamine.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you.

  • Are taking medicine or are allergic (uh-ler-jik) to any medicine (prescription or over-the-counter (OTC) or diet supplement)
  • Are pregnant or plan to become pregnant while using this medicine
  • Are breastfeeding
  • Have a history of seizures
  • Have other health problems, such as high blood pressure or heart or blood vessel disease

Dosage:

Talk with your caregiver about how much DMAE you should take. The amount depends on the strength of the medicine and the reason you are taking DMAE. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to. Take this medicine with a full glass of water.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine.

Warnings:

  • Before taking DMAE, tell your doctor if you are pregnant or breastfeeding

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms. This may mean that you are allergic (uh-ler-jik) to the medicine.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine or if you have any of the following problems.

  • You have chest pain, palpitations (unusual heartbeats), or shortness of breath (3,4)
  • You have trouble concentrating (1-4)
  • You cannot sleep (1-4)
  • You feel anxious or jittery (1-4)
  • A family member or friend tells you that your behavior is different than usual (1-4)
  • You have an upset stomach (3)

References:

1. Escobar JI and Kemp KF: Dimethylaminoethanol for tardive dyskinesia. N Eng J Med 1975; 292 (6): 317-318.

2. Jus A, Villeneuve A, Gautier J et al: Deanol, lithium, and placebo in the treatment of tardive dyskinesia. Neuropsychobiology 1978; 4:140-149.

3. Laterre EC & Fortemps E: Deanol in spontaneous and induced dyskinesias. Lancet 1975; 1(7919):1301.

4. Lindeboom SF & Lakke JPWF: Deanol and physostigmine in the treatment of l-dopa induced dyskinesias. Acta Neurol Scand 1978; 58:134-138.

5. Dimpfel W, Hofmann HC, Prohaska A et al: Source density analysis of functional topographical EEG: monitoring of cognitive drug action. Eur J Med Res 1995/1996; 1:283-290.

6. Jameson HD, Blacker HM & Fuchs ME: Hemiballismus-Hemichorea treated with dimethylaminoethanol. Dis Nervous Sys 1977; November:931-932.

7. Traub RG, Madden DL, Fuccillo DA et al: Dimethyl aminoethanol in the treatment of blepharospasm. N Engl J Med 1973; 289(13):697.

8. Ray I: Tardive dyskinesia treated with deanol acetamidobenzoate. CMA Journal 1977; 177:129.

9. Davis KL, Berger PA & Hollister LE: Deanol in tardive dyskinesia. Am J Psychiatry 1977; 134(7):807.

10. Tarsy D & Bralower M: Deanol acetamidobenzoate treatment in choreiform movement disorders. Arch Neurol 1977; 34:756-758.

11. De Silva L & Huang CY: Deanol in tardive dyskinesia. Brit Med J 1975; 5981(3):466.


Last Updated: 11/4/2014

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