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Pomegranate

What is it?

Pomegranate is an herbal medicine used as an antioxidant, to prevent hardening of the arteries (atherosclerosis) and to treat parasite infections.

Other names for Pomegranate include: Granada, Grenadier, Punicaceae, Punica Granatum L..

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have other health problems, such as high blood pressure or heart or blood vessel disease

Dosage:

Talk with your caregiver about how much Pomegranate you should take. The amount depends on the strength of the medicine and the reason you are taking Pomegranate. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take pomegrante without talking to your doctor first if you are taking:

  • Blood thinning medicine (examples: warfarin (Coumadin(R)) (7)

Warnings:

  • Before taking Pomegranate, tell your doctor if you are pregnant or breastfeeding
  • Pomegranate fruit should not be taken if you have diarrhea (loose bowel movements) (3)
  • In Traditional Chinese Medicine, Pomegranate fruit should not be taken with oil or fats when used to treat parasite infections (4)
  • Pomegranate root or stem bark should be used only under direct supervision of an expert qualified in its use (3)
  • Large amounts of aflatoxin B-1 are found in dried Pomegranate peel. Aflatoxin has been shown to cause certain cancers (5)

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Allergic reactions have occurred, including severe reactions like anaphylaxis. Some people who are allergic to Pomegranate are also allergic to other fruits, pollen, or nuts (6)

References:

1. Aviram M, Dornfeld L, Rosenblat M et al: Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 2000; 71(5):1062-1076.

2. Chung KT, Wong TY, Wei CI et al: Tannins and human health: a review. Crit Rev Food Sci Nutrition 1998; 38(6):421-464.

3. McGuffin M, Hobbs C, Upton R et al (eds): American Herbal Products Association's Botanical Safety Handbook. CRC Press, Boca Raton, FL; 1997.

4. Bensky D, Gamble A & Kaptchuk T (eds): Chinese Herbal Medicine: Materia Medica, revised edition. Eastland Press Inc., Seattle, WA; 1993.

5. Selim MI, Popendorf W, Ibrahim MS et al: Aflatoxin B1 in common Egyptian foods. J AOAC Int 1996; 79(5):1124-1129.

6. Gaig P, Bartolome B, Lleonart R et al: Allergy to pomegranate. Allergy 1999; 54(3):287-296.

7. Komperda KE: Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009; 29(8):1002-1006.


Last Updated: 11/4/2014

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