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Manganese

What is it?

Manganese is a mineral that is found in whole grains, cereals, fruits, vegetables, and tea. It is used as a supplement for diabetes, epilepsy (seizures), high cholesterol (blood fats), Parkinson's disease, rheumatoid arthritis, and schizophrenia. Manganese is also used for strains, sprains, and inflammation (soreness and swelling).

Other names for Manganese include: Manganese Sulfate, Manganese Chloride, Manganese Picolinate, and Manganese Gluconate.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure or heart or blood vessel disease

Dosage:

Talk with your caregiver about how much Manganese you should take. The amount depends on the strength of the medicine and the reason you are taking Manganese. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

  • Take Manganese without food (on an empty stomach) for more of it to get into your body

Warnings:

  • Before taking Manganese, tell your doctor if you are pregnant or breastfeeding
  • Inhaling (breathing in) Manganese (examples, mining and environmental exposure) can produce psychiatric symptoms such as hallucinations, violent acts, and hyperirritability
  • Manganese should not be used in persons with liver or kidney problems

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Tell your doctor if you develop high blood pressure. This has been occasionally reported in people over 40 taking supplemental Manganese
  • Muscle weakness, trouble speaking, nervousness, abnormal behavior, and memory problems are signs of overdose
  • Liver problems

References:

1. Murray, MT: Encyclopedia of Nutritional Supplements. Prima Publishing, Rocklin, CA; 1996.

2. Rubenstein AH, Levin NW, Elliot GA: Manganese-induce hypoglycemia. Lancet 1962;2:1348-1351.

3. Everson GJ & Schrader RE: Abnormal glucose tolerance in manganese-deficient guinea pigs. J Nutr 1968;94;89-94.

4. Manganese and glucose tolerance. Nutr Rev 1968;26(7):207-209.

5. Papavasiliou PS, Kutt H, Miller ST et al: Seizure disorders and trace metals: Manganese tissue levels in treated epileptics. Neurology 1979;29:1466.

6. Pfeiffer CC, Lamola S: Zinc and manganese in the schizophrenias. J Orthomol Psychiat 1983;12:215-234.

7. Sampson P: Low manganese level may trigger epilepsy. JAMA 1977;238:1805.

8. Keen CL & Zidenberg-Cheer S: Manganese. In: Brown ML (ed): Present knowledge in nutrition, 6th ed. International Life Sciences Institute, Washington, DC; 1990:279-286.

9. Krieger D, Krieger S, Jansen O et al: Manganese and chronic hepatic encephalopathy. Lancet 1995; 346:270-274.

10. Riley MR (ed): Drug Facts and Comparisons. Facts and Comparisons Inc, St. Louis, MO; 2000: 14a.

11. Mehta R & Reilly JJ: Manganese levels in a jaundiced long-term total parenteral nutrition patient: Potentiation of haloperidol toxicity: Case report and literature review. J Parenter Enter Nutr 1990; 14(4):428-430.

12. Anon: Manganese deficiency in humans: fact or fiction? Nutr Rev 1988; 46(10):348-352.

13. Chandra SV, Shukla GS, Singh H et al: An exploratory study of manganese exposure to welders. Clin Toxicol 1981; 18:407-416.

14. Beath SV, Gopalan S & Booth IW: Manganese toxicity and parenteral nutrition. Lancet 1996; 347(9017):1773-1774.

15. Sandstrom B, Davidsson L, Eriksson R et al: Retention of selenium ((75)Se), zinc ((65)Zn), and manganese ((54)Mn) in humans after intake of a labeled vitamin and mineral supplement. J Trace Elem Electrolytes Health Dis 1987; 1(1):33-38.


Last Updated: 11/4/2014

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