Skip to main content

Myo-inositol

What is it?

Myo-Inositol is produced in many human tissues and it is also found in many food sources. The best sources of Myo-Inositol are fruits, beans, grains, and nuts. Fresh vegetables and fruits contain more Myo-Inositol than frozen, canned, or salt-free products. Cantaloupe and citrus fruits other than lemons are very rich in Myo-Inositol and oats and bran contain more than other grains. There is very little Myo-Inositol in milk and yogurt. Myo-Inositol has been used in the treatment of liver disease, depression, panic disorder, diabetic neuropathy (damage to the nerves which results in pain and numbness), respiratory distress syndrome (found in premature babies due to poor lung development), and to treat the side effects of the medicine lithium.

Other names for Myo-Inositol include: Inositol, Inositol Monophosphate, and Inositol Hexaphosphate

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are allergic to bismuth salts
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have any other health problems, such as high blood pressure, liver or kidney problems, or heart or blood vessel disease

Dosage:

Talk with your caregiver about how much Myo-Inositol you should take. The amount depends on the strength of the medicine and the reason you are taking Myo-Inositol. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Warnings:

  • Before taking Myo-Inositol, tell your doctor if you are pregnant or breastfeeding
  • Do not use Myo-Inositol with the medicine lithium without talking to your doctor (11,12,13,14,15)

Side Effects:

Stop taking your medicine right away and talk to your doctor if you have any of the following side effects. Your medicine may be causing these symptoms which may mean you are allergic to it.

  • Breathing problems or tightness in your throat or chest
  • Chest pain
  • Skin hives, rash, or itchy or swollen skin

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Loose stools (16), stomach gas (2), nausea (2), and increased mood (17) have been reported with the use of Myo-Inositol

References:

1. Murray, MT: Encyclopedia of Nutritional Supplements. Prima Publishing, Rocklin, CA; 1996.

2. Levine J, Barak Y, Gonzalves M et al: double blind controlled trial of inositol treatment of depression. Am J Psychiatry 1995;152:792-794.

3. Benjamin J, Levine J, Fux M et al: Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. AM J psychiatry 1995;152:1084-1086.

4. Gegersen G, Harb H, Helles A & Christensen J: Oral supplementation of myoinositol: Effects on peripheral nerve function in human diabetics and on the concentration in plasma, erythrocytes, urine and muscle tissue in human diabetics and normals. Acta Neurol Scand 1983;67:164-171.

5. Clements RS, Bourganti B, Kuba T et al: Dietary myo-inositol intake and peripheral nerve function in diabetic neuropathy. Metabolism 1979;28:477.

6. Salway JG, Whitehead I, Finnegan JA et al: Effect of myo-inositol on peripheral-nerve function in diabetes. Lancet 1978; 2:1282.

8. Levine J, Gonsalves M, Barbur I et al: Inositol 6g daily may be effective in depression but not in schizophrenia. OGY 1993; 8:49-53.

9. Grisaru N & Belmaker R: Lithium dosage and inositol levels. Br J Psychiatry 1993; 164(1):133-134.

10. Sandberg AS, Brune M, Carlsson NG et al: Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans. Am J Clin Nutr 1999; 70:240-246.

11. Belmaker RH, Agam G, van Calker D et al: Behavioral reversal of lithium effects by four inositol isomers correlates perfectly with biochemical effects on the PI cycle: depletion by chronic lithium of brain inositol is specific to hypothalamus, and inositol levels may be abnormal in postmortem brain from bipolar patients. Neuropsychopharmacology 1998; 19(3):220-32.

12. Wolfson M, Hertz E, Belmaker RH et al: Chronic treatment with lithium and pretreatment with excess inositol reduce inositol pool size in astrocytes by different mechanisms. Brain Res 1998; 787(1):34-40.

13. Fauroux CM & Freeman S: Inhibitors of inositol monophosphatase. J Enzyme Inhib 1999; 14(2):97-108.

14. Moore GJ, Bebchuk JM, Parrish JK et al: Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. Am J Psychiatry 1999; 156(12):1902-1908.

15. Lubrich B & van Calker D: Inhibition of the high affinity myo-inositol transport system: a common mechanism of action of antibipolar drugs? Neuropsychopharmacology 1999; 21(4):519-529.

16. Arendrup K, Gregersen G & Hawley J: High-dose dietary myo-inositol supplementation does not alter the ischaemia phenomenon in human diabetics. Acta Neurol Scand 1989:99-102.

17. Levine J, Witztum E, Greenberg B et al: Inositol-induced mania? Am J Psych 1996; 153:6.


Last Updated: 4/4/2014

Copyright © 1984- Thomson Micromedex. All rights reserved.

Thomson & A.D.A.M