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Guggul

What is it?

Guggul is an herbal medicine used for lowering high cholesterol and triglycerides (blood levels of fats).

Other names for guggul include: Commiphora mukul, gugglu, gum guggulu, and guggal.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement).
  • are pregnant or plan to become pregnant while using this medicine (4,13).
  • are breastfeeding.
  • have any other health problems, such as high blood pressure or heart or blood vessel disease.

Dosage:

Talk with your caregiver about how much guggul you should take. The amount depends on the strength of the medicine and the reason you are taking Guggul. If you are using this medicine without instructions from your caregiver, follow the directions on the medicine bottle. Do not take more medicine or take it more often than the directions tell you to.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take guggul without talking to your doctor first if you are taking:

  • Blood thinning medicine (examples: aspirin; clopidogrel (Plavix(R)); ticlopidine (Ticlid(R)); warfarin (Coumadin(R)); enoxaparin (Lovenox(R))) (5,14,15)
  • Diltiazem (Cardizem(R), Tiazac(R), Dilacor(R))) (1,8,10)
  • Propranolol (Inderal(R)) (1,8,10)
  • Sulfinpyrazone (Anturane(R)) (5,14,15)

Warnings:

  • Before taking guggul, tell your doctor if you are pregnant or breastfeeding.

Side Effects:

Call your doctor right away if you have any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hand, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, or rash

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Mild diarrhea, nausea, stomach pain.
  • Headache
  • Hiccups
  • Restlessness

References:

1. Dalvi SS, Nayak Vk, Pohujani SM et al: Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Physicians India 1994; 42(6):454-455.

2. Beg M, Singhal KC & Afzaal S: A study of effect of Guggulsterone on hyperlipidemia of secondary glomerulopathy. Indian J Physiol Pharmacol 1996; 40(3):237-240.

3. Kuppurajan K, Rajagopalan SS, Rao TK et al: Effect of Guggulu (commiphoramukul-engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. Jr Asso Phys Ind 1978; 26:367-373.

4. McGuffin M, Hobbs C, Upton R et al (eds): American Herbal Products Association: Botanical Safety Handbook. CRC Press, Boca Raton, FL; 1997.

5. Mester L, Mester M & Nityanand S: Inhibition of platelet aggregation by "Guggulu" steroids. Planta Medica 1979; 37:367-369.

6. Nityanand S, Srivastava JS & Asthana OP: Clinical trials with gugulipid-a new hypolipidaemic agent. JAPI 1989; 37(5):323-328.

7. Paranjpe P, Patki P & Patwardhan B: Ayurvedic treatment of obesity: a randomized double-blind, placebo-controlled trial. J Ethnoplarmacol 1990; 29(1):1-11.

8. Sharma SB & Dwivedi S: Review article-medicinal plants with hypolipidemic activities. Indian Drugs 1997; 34(5):242-251.

9. Singh RP, Singh R, Ram P et al: Use of Pushkar-Guggul, an indigenous antiischemic combination, in the management of ischemic heart disease. Int J Pharmacog 1993; 31(2):147-160.

10. Singh RB, Niaz MA & Ghosh S: Hypolipidemic and antioxidant effects of commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovascular Drugs and Therapy 1994; 8:659-664.

11. Szapary P, Wolfe M, Bloedon et al: Guggulipids for the treatment of hypercholesterolemia. JAMA 2003; 290(6):765-769.

12. Thappa DM & Dogra J: Nodulocystic acne: oral gugulipid versus tetracycline. J Dermatol 1994; 21(10): 729-731.

13. Kakrani HK: Guggul--a review. Indian Drugs 1981; September:417-421.

14. Bordia A & Chuttani SK: Effect of gum guggulu on fibrinolysis and platelet adhesiveness in coronary heart disease. Indian J Med Res 1979; 70(Dec):992-996.

15. Tripathi SN, Shastri VVS & Scharya GVS: Experimental and clinical studies on the effect of guggulu (Commiphora mukul) in hyperlipemia and thrombosis. J Res Indian 1968; 2:140-154.


Last Updated: 4/4/2014

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