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Coenzyme q10

What is it?

Coenzyme Q10 is a dietary supplement that has strong antioxidant effects in the body. It is used to treat heart and lung disease, high blood pressure, and muscle problems. It may also be used to treat male infertility, migraine headaches, and Parkinson's disease.

Other names for coenzyme Q10 include: CoQ10, ubiquinone, and coenzyme Q.

Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information in this leaflet concerns you.

Before Using:

Tell your doctor if you

  • are taking medicine or are allergic to any medicine (prescription or over-the-counter (OTC) or dietary supplement)
  • are pregnant or plan to become pregnant while using this medicine
  • are breastfeeding
  • have diabetes or liver disease
  • have any other health problems, such as high blood pressure or heart or blood vessel disease

Dosage:

Talk with your caregiver about how much coenzyme Q10 you should take. The amount depends on the strength of the medicine and the reason you are taking coenzyme Q10. If you are using this medicine without instructions from your caregiver, follow the directions on the label. Do not take more coenzyme Q10 or take it more often than the directions tell you to.

Coenzyme Q10 works best when taken with food.

To store this medicine:

Keep all medicine locked up and away from children. Store medicine away from heat and direct light. Do not store your medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down and not work the way it should work. Throw away medicine that is out of date or that you do not need. Never share your medicine with others.

Drug and Food Interactions:

Do not take coenzyme Q10 without talking to your doctor first if you are taking:

  • Blood thinning medicine (warfarin (Coumadin(R))

Warnings:

  • Before taking coenzyme Q10, tell your doctor if you are pregnant or breastfeeding.
  • Do not take coenzyme Q10 if you have diabetes.

Side Effects:

Call your doctor right away if you have any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hand, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, or rash.

Other Side Effects:

You may have the following side effects, but this medicine may also cause other side effects. Tell your doctor if you have side effects that you think are caused by this medicine.

  • Diarrhea, nausea, or heartburn
  • Dizziness, headache, irritability, or loss of appetite
  • Mild skin rash with itching

References:

1. Baggio E, Gandini R, Plancher AC et al: Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med 1994; 15(suppl):S287-S294.

2. Greenberg S & Frishman WH: Coenzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990; 30: 596-608.

3. Kishi H, Kishi T & Folkers K: Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used antihypertensive drugs. Res Comm Chem Pathol Pharmacol 1975; 12:533-540.

4. Langsjoen PH, Langsjoen A, Willis R et al: Treatment of hypertrophic cardiomyopathy with coenzyme Q10. Mol Aspects Med 1997; 18(suppl):S145-S151.

5. Langsjoen PH, Langsjoen PH & Folkers K: Long-term safety and efficacy of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990; 65:521-523.

6. Matthews PM, Ford B, Dandurand RJ et al: Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993; 43: 884-890.

7. Mortensen SA: Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin Invest 1993; 71:116-123.

8. Spigset O: Reduced effect of warfarin caused by ubidecarenone. Lancet 1994; 344:1372-1373.

9. Watts GF, Castelluccio C, Rice-Evans C et al: Plasma coenzyme Q10 (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol 1993; 46: 1055-1057.


Last Updated: 4/4/2014

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